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Colorado vs Houston Prediction 9/12/2025 Today’s College Football Picks

Aug 28, 2025; Houston, Texas, USA; Houston Cougars quarterback Conner Weigman (1) warms up before the game against the Stephen F. Austin Lumberjacks at TDECU Stadium. Mandatory Credit: Troy Taormina-Imagn Images

Aug 28, 2025; Houston, Texas, USA; Houston Cougars quarterback Conner Weigman (1) warms up before the game against the Stephen F. Austin Lumberjacks at TDECU Stadium. Mandatory Credit: Troy Taormina-Imagn Images

MATCHUP Buffaloes Colorado Cougars Houston
Team Records 1-2 3-0
Where TDECU Stadium, Houston, TX
When Friday, September 12, 2025
Time 07:30 PM EDT

The Colorado Buffaloes and the Houston Cougars meet in week 3 college football action from TDECU Stadium on Friday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Colorado Buffaloes vs. Houston Cougars prediction.

Colorado Buffaloes Recap

The Colorado Buffaloes come into this game looking to build on their 31-7 win over Delaware last time out to sit at 1-1 on the year. After this game, the Buffaloes will head home for a game against the Wyoming Cowboys.

Buffaloes Looking To Build On Opening Win

Kaidon Salter has thrown for 261 yards and a touchdown on 68.2% passing while Ryan Staub has thrown for 157 yards and 2 TDs on 7 of 10 passing. Simeon Price leads the Buffs with 85 rushing yards while Micah Welch has 78 rushing yards with a TD and Kaidon Salter has 68 rushing yards and 2 TDs. Sincere Brown has 120 receiving yards and a touchdown to lead Colorado while Dekalon Taylor has a team-high 7 receptions for 87 yards and 2 touchdowns. On defense, Reginald Hughes has a team-high 14 total tackles including 8 solo tackles while Colorado’s defense as a whole has combined for 3 sacks and 2 interceptions this season. 

Houston Cougars Recap

The Houston Cougars come into this game looking to add on to their 35-9 win over Rice last time out to sit at 2-0 on the year. After this game, Houston will head on the road for a game against the Oregon State Beavers.

Cougars Looking To Remain Unbeaten

Connor Weigman has thrown for 347 yards and 4 touchdowns on 65.2% passing while Dean Connors has rushed for 182 yards and 2 TDs on the ground this season. Tanner Koziol has a team-high 13 catches for 115 yards and a touchdown to lead Houston’s receiving group. On defense, Jalen Garner and Latrell McCutchin Sr. each have a team-high 13 total tackles while Brandon Mack II has a team-high 1.5 sacks. As a unit, Houston’s defense has combined for 5 sacks and 3 interceptions so far this season.

Colorado Buffaloes @ Houston Cougars Betting Trends: Week 3

Why the Houston Cougars will win

Why the Colorado Buffaloes will win

Total Points Facts

Houston Cougars Player Prop Facts

Colorado Buffaloes Player Prop Facts

Matchup/League Facts

Colorado Buffaloes vs. Houston Cougars Prediction

I’m leaning towards Colorado and the points here. It’ll be interesting to see how Deion Sanders and the Buffaloes navigate this quarterback situation they have going on, but I think they’ll weather the storm just fine as there are a bunch of solid options in the Black and Gold. Houston has some QB stability with Weigman, but the Buffs have been great under Deion as an underdog, and I just think this is a field goal kind of game. Give me the Buffs and the points.

Chris Ruffolo's Pick: Colorado +5.5

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