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Georgia Southern vs USC Prediction 9/6/2025 Today’s College Football Picks

Dec 27, 2024; Las Vegas, NV, USA; Southern California Trojans quarterback Jayden Maiava (14) throws the ball against the Texas A&M Aggies in the first half at Allegiant Stadium. Mandatory Credit: Kirby Lee-Imagn Images

Dec 27, 2024; Las Vegas, NV, USA; Southern California Trojans quarterback Jayden Maiava (14) throws the ball against the Texas A&M Aggies in the first half at Allegiant Stadium. Mandatory Credit: Kirby Lee-Imagn Images

MATCHUP Georgia Southern Eagles USC Trojans
Team Records 0-2 2-0
Where Los Angeles Memorial Coliseum, Los Angeles, CA
When Saturday, September 6, 2025
Time 07:30 PM EDT

The Georgia Southern Eagles and the USC Trojans meet in week 2 college football action from the Los Angeles Memorial Coliseum on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Georgia Southern Eagles vs. USC Trojans prediction.

Georgia Southern Eagles Recap

The Georgia Southern Eagles come into this game looking to bounce back from a 42-14 loss at the hands of the Fresno State Bulldogs last time out to slip to 0-1 this season. After this game, the Eagles will head home for a game against the Jacksonville State Gamecocks.

Eagles Looking For Bounce Back

JC French IV threw for 158 yards, 2 touchdowns and an interception on 17 of 28 passing while OJ Arnold had 9 carries for 41 yards and Camden Brown led Georgia Southern’s receiving group with 55 receiving yards and a touchdown coming on 4 catches. Josh Dallas had a team-high 5 grabs for 48 yards while River Helms added a receiving TD as well. On defense, Jayden Davis led the Eagles with 10 total tackles including 6 solo tackles while Chance Gamble and Brandon Tyson each had an interception on in the losing effort.

Why the Georgia Southern Eagles will win

USC Trojans Recap

The USC Trojans come into this game looking to add on to their 73-13 rout over Missouri State last time out to sit at 1-0 on the year. After this game, the Trojans will head on the road for a game against the Purdue Boilermakers. 

Trojans Looking To Add On To Rout

Jayden Maiava threw for 295 yards and 2 touchdowns on 15 of 18 passing while Husan Longstreet threw for 69 yards and a score on 9 of 9 passing while also rushing for 54 yards and 2 TDs. Maiava also had a TD while King Miller led USC with 4 carries for 80 yards and a score. Waymond Jordan also chipped in 42 rushing yards and a touchdown. Makai Lemon led the Trojans with 7 grabs for 90 yards while Eli Sanders had 73 receiving yards with a touchdown and Lake McRee added 72 receiving yards and a TD. Carson Tabaracci also chipped in a receiving score. On defense, Elijah Newby led the Trojans with 5 total tackles including 4 solo tackles while Braylan Shelby had a pair of sacks and Kennedy Urlacher, Kameryn Fountain and Jide Abasiri each had a sack. Bishop Fitzgerald added a 39-yard pick-six for the USC defense and Garrett Pomerantz added an interception of his own.

Why the USC Trojans will win

Total Points Facts

Georgia Southern Eagles vs. USC Trojans Prediction

I’m on USC here. It’s a huge number, and maybe I’m backing USC out of spite after Georgia Southern burned me last week, but I just think that the Eagles looked horrible last week and I’m in no position to want to back them in any way, shape or form here. The defense is still a huge problem, and now you have to take on a Trojan team that just hung 73 on Missouri State? I look for this one to be over fairly quickly and for USC to have this one wrapped up, done and dusted by halftime. Give me USC.

Chris Ruffolo's Pick: USC -27.5

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