Houston vs Oregon State Prediction 9/26/2025 Today’s College Football Picks

Chris Ruffolo

2 months ago

Sep 12, 2025; Houston, Texas, USA; Houston Cougars quarterback Conner Weigman (1) runs with the ball during the first quarter against the Colorado Buffaloes at TDECU Stadium. Mandatory Credit: Troy Taormina-Imagn Images

MATCHUP	Cougars Houston	Beavers Oregon State
Team Records	3-0	0-4
Where	Reser Stadium, Corvallis, OR
When	Friday, September 26, 2025
Time	10:30 PM EDT
TV	ESPN

The Houston Cougars and the Oregon State Beavers meet in week 5 college football action from Reser Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Houston Cougars vs. Oregon State Beavers prediction.

Houston Cougars Recap

The Houston Cougars come into this game looking to add on to their 36-20 win over Colorado last time out to improve to 3-0 this season. After this game, Houston will head home for a game against Texas Tech.

Cougars Looking To Stay Unbeaten

Connor Weigman has thrown for 569 yards and 4 touchdowns on 64.3% passing while Dean Connors has rushed for 271 yards and 3 TDs on the ground this season. Weigman and Stacy Sneed each have 100+ rushing yards as well with Weigman adding 3 rushing TDs. Stephon Johnson has a team-high 191 receiving yards and a touchdown while Tanner Koziol has a team-high 17 catches for 148 yards and a touchdown and Amare Thomas has 110 receiving yards as well this season. On defense, Jalen Garner has a team-high 20 total tackles while Eddie Walls III and Corey Platt Jr. each have a team-high 2 sacks. As a unit, Houston’s defense has combined for 8 sacks and 5 interceptions so far this season.

Oregon State Beavers Recap

The Oregon State Beavers come into this game looking to bounce back from a 41-7 loss at the hands of Oregon last time out to fall to 0-4 this season. After this game, Oregon State will head on the road for a game against App State.

Oregon State Still Searching For First W

Maalik Murphy has thrown for 964 yards, 6 touchdowns and 5 interceptions on 57.3% passing while Anthony Hankerson has a team-high 228 rushing yards and 2 touchdowns so far this season. Trent Walker has a team-high 23 receptions for 302 yards while Taz Reddicks has 240 receiving yards and David Wells Jr. has 170 receiving yards as well this season. On defense, Skyler Thomas and Dexter Foster each have a team-high 31 total tackles while the Oregon State defense as a whole has combined for 3 sacks and 3 interceptions so far this season.

Houston Cougars @ Oregon State Beavers Betting Trends: Week 5

Why the Oregon State Beavers will win

Oregon State has won 11 of its last 12 September games against non-AP-ranked teams.
Houston has lost five of its last six road games in September.
Oregon State has covered the spread in 10 of its last 12 September games against non-AP-ranked teams.
Houston has failed to cover the spread in three of its last four September road games against non-AP-ranked teams.
Houston has lost the first half in four of its last five road games against non-conference opponents.

Why the Houston Cougars will win

Oregon State has lost each of its last 10 games against non-conference opponents.
The favorite has won each of Houston’s last six games.
Oregon State has failed to cover the spread in each of its last eight games against non-AP-ranked teams.
Houston has covered the spread in each of its last four games.
Oregon State has lost the first half in each of its last six games against non-conference opponents.

Total Points Facts

Ten of Houston’s last 11 September road games against non-AP-ranked teams have gone OVER the total points line.
Each of Oregon State’s last three home games have gone OVER the total points line.

Oregon State Beavers Player Prop Facts

Heading into Week 5, Anthony Hankerson leads the Pac-12 Conference for touchdowns (2) this season.

Houston Cougars Player Prop Facts

Heading into Week 5, Stephon Johnson ranks 1st amongst qualified players for Yards Per Reception (31.8) this season.

Matchup/League Facts

Oregon State ranks 134th among FBS teams for average point differential in second quarters this season (-8.0).
Oregon State ranks 133rd among FBS teams for rushing yards per game this season (70.0).
Houston ranks T1st among FBS teams for Q1 opponent points per game this season (0.0).
Houston ranks T1st among FBS teams for Q3 opponent points per game this season (0.0).

Houston Cougars vs. Oregon State Beavers Prediction

I’m on the Cougars here. It’s a big number to lay on the road, but Corvallis is not what it used to be, as it’s just not been the home field advantage that the Beavers have utilized to their advantage in the past, and the fact is that even if it was, this Oregon State roster is not built to compete on either side of the ball. I think Houston runs away with this one so I’ll lay the points with Houston here.