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Louisiana vs Eastern Michigan Prediction 9/20/2025 Today’s College Football Picks

Sep 13, 2025; Lexington, Kentucky, USA; Eastern Michigan Eagles running back Dontae McMillan (28) celebrates after running the ball during the second quarter against the Kentucky Wildcats at Kroger Field. Mandatory Credit: Jordan Prather-Imagn Images

Sep 13, 2025; Lexington, Kentucky, USA; Eastern Michigan Eagles running back Dontae McMillan (28) celebrates after running the ball during the second quarter against the Kentucky Wildcats at Kroger Field. Mandatory Credit: Jordan Prather-Imagn Images

MATCHUP Ragin' Cajuns Louisiana Eagles Eastern Michigan
Team Records 1-3 1-3
Where Rynearson Stadium, Ypsilanti, MI
When Saturday, September 20, 2025
Time 03:30 PM EDT
TV ESPN+
The Louisiana-Lafayette Ragin’ Cajuns and Eastern Michigan Eagles meet Saturday in college football action at Rynearson Stadium. Here’s a Louisiana vs Eastern Michigan Prediction. This article will include a Louisiana vs Eastern Michigan Pick.

Louisiana-Lafayette Ragin’ Cajuns Betting Preview


The Louisiana-Lafayette Ragin’ Cajuns beat McNeese, lost to Missouri, and they play Marshall next. The Louisiana-Lafayette Ragin’ Cajuns have lost 4 of their last 5 games. Daniel Beale is completing 41.7 percent of his passes for 91 yards, 1 touchdown, and 0 interceptions. Shelton Sampson Jr. and KeDarius Wade have combined for 88 receiving yards on 7 catches, while Caden Jensen has 5 receptions.

The Louisiana-Lafayette Ragin’ Cajuns ground game is averaging 194.3 yards per contest, and Zylan Perry leads the way with 226 yards and 1 touchdown. Defensively, Louisiana-Lafayette is allowing 25.3 points and 365 yards per game. Jaden Dugger leads the Louisiana-Lafayette Ragin’ Cajuns with 24 tackles, Jaelen Crider has 1 sack and Cameron Whitfield has 1 interception.

Eastern Michigan Eagles Betting Preview


The Eastern Michigan Eagles lost to LIU and Kentucky, and they play Central Michigan next week. Eastern Michigan has lost 8 straight games. Noah Kim is completing 62.9 percent of his passes for 767 yards, 4 touchdowns, and 1 interception. Terry Lockett Jr. and Joshua Long have combined for 338 receiving yards and 2 touchdowns, while Dontae McMillan has 7 receptions.

The Eastern Michigan Eagles ground game is averaging 132 yards per contest, and Dontae McMillan leads the way with 219 yards and 1 touchdown. Defensively, Eastern Michigan is allowing 42.7 points and 525.7 yards per game. Marco Patierno leads the Eastern Michigan Eagles with 19 tackles, Messiah Blair has 1 sack and Joshua Scott has 2 pass deflections.

Louisiana Ragin’ Cajuns @ Eastern Michigan Eagles Betting Trends: Week 4


Why the Eastern Michigan Eagles will win

Why the Louisiana Ragin’ Cajuns will win

Total Points Facts

Eastern Michigan Eagles Player Prop Facts

Louisiana Ragin’ Cajuns Player Prop Facts

Matchup/League Facts

Louisiana vs Eastern Michigan Prediction


I’m not excited to lay chalk with Louisiana on the road, as the Ragin Cajuns have shown little offensively and can’t stop the run on defense. However, Eastern Michigan may be the worst defense in the country and has that stain of a loss to Long Island on its resume. It’s impossible to get behind Eastern Michigan with confidence. There’s much better games out there on a packed CFB Saturday card, but if forced to pick, I’m siding with Louisiana. Few teams have gotten off to a worse start than Eastern Michigan.

Randy Chambers's Pick: Louisiana -2.5

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