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Old Dominion vs Virginia Tech Prediction 9/13/2025 Today’s College Football Picks

Sep 6, 2025; Blacksburg, Virginia, USA;  Virginia Tech Hokies quarterback Kyron Drones (1) looks to pass the ball during the fourth quarter at Lane Stadium. Mandatory Credit: Brian Bishop-Imagn Images

Sep 6, 2025; Blacksburg, Virginia, USA; Virginia Tech Hokies quarterback Kyron Drones (1) looks to pass the ball during the fourth quarter at Lane Stadium. Mandatory Credit: Brian Bishop-Imagn Images

MATCHUP Monarchs Old Dominion Hokies Virginia Tech
Team Records 2-1 0-3
Where Lane Stadium, Blacksburg, VA
When Saturday, September 13, 2025
Time 07:00 PM EDT

The Old Dominion Monarchs and the Virginia Tech Hokies meet in week 3 college football action from Lane  Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Old Dominion Monarchs vs. Virginia Tech Hokies prediction.

Old Dominion Monarchs Recap

The Old Dominion Monarchs come into this game looking to add on to their 54-6 win over NC Central last time out to sit at 1-1 on the year. After this game, Old Dominion will head home for a matchup with Liberty.

Monarchs Looking For Big Road Win

Colton Joseph has thrown for 353 yards, 3 touchdowns and 3 interceptions on 65.2% passing while also rushing for 228 yards and 3 TDs on the ground as well. Trequan Jones also has 163 rushing yards with 3 touchdowns this season while Ja’Cory Thomas has 8 catches for 110 yards and a score and Tre’ Brown III has 7 catches for 101 yards as well on the year. On defense, Mario Easterly has a team-high 20 total tackles while Jerome Carter has 16 total tackles including a team-high 10 solo tackles. Jeremy Mack Jr. has a pair of sacks to lead ODU while the Monarchs as a unit have combined for 3 sacks and a pair of INTs so far this season.

Virginia Tech Hokies Recap

The Virginia Tech Hokies come into this game looking to rebound from a 44-20 loss at the hands of Vanderbilt last time out to sit at 0-2 this season. After this game, Virginia Tech will take on the Wofford Terriers at home.

Hokies Searching For First Win Of The Year

Kyron Drones has thrown for 355 yards, a touchdown and 2 interceptions on 50% passing while Marcellous Hawkins leads Virginia Tech in rushing with 87 rushing yards on 23 carries. Donavon Greene has a team-high 116 receiving yards while Ayden Greene has a team-high 7 grabs for 81 yards.On defense, Michael Short leads the Hokies with 16 total tackles while Virginia Tech’s defensive unit as a whole has combined for 4 sacks and an interception so far this season.

Old Dominion Monarchs @ Virginia Tech Hokies Betting Trends: Week 3

Why the Virginia Tech Hokies will win

Why the Old Dominion Monarchs will win

Total Points Facts

Virginia Tech Hokies Player Prop Facts

Old Dominion Monarchs Player Prop Facts

Matchup/League Facts

Old Dominion Monarchs vs. Virginia Tech Hokies Prediction

I’m on the Monarchs and the points here. I’m just not loving the Hokies with Drones at QB, and this is a Virginia Tech team that’s been a shell of what past Hokie teams have been in Blacksburg. ODU has looked better in limited action so far and I think at worst, the Monarchs keep it within the number. Give me the Monarchs and the points in this one.

Chris Ruffolo's Pick: Old Dominion +7

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