South Carolina State vs South Florida Prediction 9/20/2025 Today’s College Football Picks

The South Carolina State Bulldogs and the USF Bulls meet in week 4 college football action from Raymond James Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a South Carolina State Bulldogs vs. USF Bulls prediction.

South Carolina State Bulldogs Recap

The South Carolina State Bulldogs come into this game looking to add on to their 55-41 win over Bethune Cookman last time out to improve to 2-1 on the year. After this game, South Carolina State will head on the road for a game against Charleston Southern.

Bulldogs Looking For Upset Win

Ryan Stubblefield has thrown for 500 yards and 3 touchdowns on 59.1% passing while William Atkins IV has thrown for 293 yards on 57.4% passing. KZ Adams and Mason Pickett-Hicks each have a team-high 101 rushing yards while Jalen Johnson leads South Carolina State with 13 receptions for 207 yards. Jordan Smith, Deyandre Ruffin and Shamontae Burgess each have 100+ receiving yards as well for the Bulldogs so far this season. On defense, Roderick Kelly leads SC State with 14 total tackles while Tyler Jones has a team-high 11 solo tackles and Mike Lunz has a team-high 3 sacks. 

USF Bulls Recap

The USF Bulls come into this game looking to bounce back from their 49-12 loss to Miami in their last game to slip to 2-1 on the year. After this game, USF will head home for a game against Charlotte. 

Bulls Looking To Get Back On Track Ahead Of AAC Play

Byrum Brown has thrown for 747 yards, 2 touchdowns and an interception on 61.5% passing while also leading USF in rushing with 111 rushing yards and 2 scores. Alvon Isaac has 108 rushing yards as well while  Chas Nimrod has a team-high 10 catches for 248 yards and Keshaun Singleton has 207 receiving yards with 2 touchdowns as well this season. On defense, Jhalyn Shuler has a team-high 29 total tackles including a team-high 10 solo tackles while Mac Harris has 26 total tackles including a pair of sacks and De’Shawn Rucker has 21 total tackles including 15 solo tackles of his own. James Chenault has a pair of interceptions as well for the Bulls’ defense this season. 

South Carolina State Bulldogs @ South Florida Bulls Betting Trends: Week 4

Why the South Florida Bulls will win

• South Florida has won each of its last 11 games against non-FBS teams.
• South Florida has covered the spread in nine of its last 11 games against non-conference opponents.

Why the South Carolina State Bulldogs will win

• South Florida has lost three of its last four games in September.
• South Florida has failed to cover the spread in three of its last four home games against non-AP-ranked teams.

Total Points Facts

• Each of South Florida’s last four games against non-AP-ranked teams have gone OVER the total points line.

South Florida Bulls Player Prop Facts

• Heading into Week 4, Alvon Isaac ranks T1st amongst qualified players for catch rate (100.0%) this season.

Matchup/League Facts

• South Florida ranks 132nd among FBS teams for time of possession per game this season (24:28).
• South Florida ranks T129th among FBS teams for average point differential in first quarters this season (-7.0).

South Carolina State Bulldogs vs. USF Bulls Prediction

I’m on the Bulls here. It’s a huge number that we’re not used to laying with USF, but this is a Bulls team that’s got a ton of talent and while conference play is on the horizon, it’s not like Charlotte is some world-beater. I think the Bulls treat this game with the same intensity as almost every game they’ve dealt with this season so give me USF here.

Chris Ruffolo's Pick: USF -29.5