Tulane vs Ole Miss Prediction 9/20/2025 Today’s College Football Picks

Nikos Lagouretos

2 months ago

Oklahoma Sooners defensive lineman Da'Jon Terry (95) brings down Tulane Green Wave running back Shaadie Clayton-Johnson (2) during a college football game between the University of Oklahoma Sooners (OU) and the Tulane Green Wave at Gaylord Family - Oklahoma Memorial Stadium in Norman, Okla., Saturday, Sept. 14, 2024.

MATCHUP	Green Wave Tulane	Rebels Ole Miss
Team Records	0-3	4-0
Where	Vaught-Hemingway Stadium, Oxford, MS
When	Saturday, September 20, 2025
Time	03:30 PM EDT
TV	ESPN

In this article, we will formulate a Tulane vs Ole Miss Prediction for this College Football Week 4 game on Saturday, September 20th at the Vaught-Hemingway Stadium. Let’s take a look at the prediction for this College Football matchup.

Ole Miss Preview

They are coming off a 41-35 home victory over Arkansas.

Ole Miss has a 3-0 record this season. Offensively, the Rebels average 44.7 points per game, which ranks 17th in the nation. Defensively, they allow 21.7 points per game, which ranks 71st in the nation. Ole Miss averages 541.7 total yards per game, with 211.0 rushing yards and 330.7 passing yards per game. They allow 381.7 total yards per game, 194.7 of them rushing and 187.0 passing yards per game.

Austin Simmons leads Ole Miss with 34/56 completed passes and 580 total passing yards. He also adds 69 rushing yards and 1 touchdown. Kewan Lacy leads the team in rushing yards, with 290 and 5 touchdowns, while Logan Diggs adds 97 rushing yards and 1 touchdown. Harrison Wallace III has a team-high 15 caught passes for a team-high 339 receiving yards, and has 2 touchdowns. Deuce Alexander has caught 10 passes for 155 yards.

Defensively, T.J. Dudley has a team-high 23 total tackles, 10 of them solo. Zxavian Harris leads the Rebels in sacks, with 2, while Zxavian Harris has a team-high 1 interception.

Tulane Preview

Tulane has a 2-0 record this season and are coming off a 34-27 home victory over Duke. Offensively, Tulane averages 28.0 points per game, which ranks 75th in the nation. Defensively, they allow 30.5 points per game, which ranks 106th in the nation. Tulane averages 417.7 total yards per game, with 222.0 rushing yards and 195.7 passing yards per game. They allow 370.0 total yards per game, 135.0 of them rushing and 235.0 passing yards per game.

Jake Retzlaff leads Tulane with 46/78 completed passes and 522 total passing yards. He also adds 288 rushing yards and 6 touchdowns. Javin Gordon leads the team in rushing yards, with 122, while Zuberi Mobley adds 107 rushing yards and 2 touchdowns. Omari Hayes has a team-high 13 caught passes for a team-high 143 receiving yards. Shazz Preston has caught 5 passes for 113 yards.

Defensively, Dickson Agu has a team-high 26 total tackles, 11 of them solo. Javion White adds 7 total tackles, 7 of them solo and 3 interceptions. Harvey Dyson III leads Tulane in sacks, with 1.5, while Javion White has a team-high 3 total interceptions.

Tulane Green Wave @ Ole Miss Rebels Betting Trends: Week 4

Why the Ole Miss Rebels will win

Ole Miss has won each of its last 14 games against non-conference opponents at Vaught-Hemingway Stadium.
Tulane has lost each of its last five games against AP-ranked teams.
Ole Miss has covered the spread in each of its last seven games against non-conference opponents.
Tulane has failed to cover the spread in four of its last five games as an underdog.
Ole Miss has won the first quarter in each of its last nine games against non-conference opponents.
Ole Miss has won the first half in each of its last 14 games against non-conference opponents at Vaught-Hemingway Stadium.

Why the Tulane Green Wave will win

Tulane has won each of its last four games in September.
Tulane has covered the spread in three of its last four games against top-15 AP-ranked teams.
Tulane has won the first half in four of its last five games against non-conference opponents.

Total Points Facts

Each of Ole Miss’ last four games have gone OVER the total points line.
Five of Tulane’s last six games in September have gone OVER the total points line.

Ole Miss Rebels Player Prop Facts

Heading into Week 4, Kewan Lacy leads the Southeastern Conference for rush attempts (61) this season.

Tulane Green Wave Player Prop Facts

Heading into Week 4, Javion White ranks T1st amongst FBS players for interceptions (3) this season.

Matchup/League Facts

Ole Miss ranks T1st among FBS teams for 4th down conversion percentage this season (100.0).
Ole Miss ranks T3rd among FBS teams for Q2 points per game this season (19.7).
Tulane ranks T1st among FBS teams for red zone percentage this season (100.0).
Tulane ranks T6th among FBS teams for interceptions this season (5).

Tulane vs Ole Miss Prediction

Ole Miss has won all four meetings against Tulane. In their most recent meeting back in 2023, Ole Miss won 37-20 on the road, covering the spread, as the game went under the point total. Ole Miss is 3-0 ATS in their last three meetings against Tulane, and under is 3-1 in their four meetings.

In this Tulane vs Ole Miss Prediction, Ole Miss is coming as -12.5-point home favorites. Both teams have been undefeated in their three games this season, and are both 2-1 against the spread. They have both been involved in high-scoring games so far, as they are a combined 5-0 to the over in their last 5 games, with Ole Miss having 66.4 average total points this season, and Tulane 62.5 average total points in their last two games. I expect another high-scoring game today, so take the over 60.5 points in this one.