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UConn vs Syracuse Prediction 9/6/2025 Today’s College Football Picks

Nov 9, 2024; Chestnut Hill, Massachusetts, USA; Syracuse Orange tight end Oronde Gadsden II (19) celebrates with wide receiver Trebor Pena (2) after scoring a touchdown against the Boston College Eagles during the first half at Alumni Stadium. Mandatory Credit: Brian Fluharty-Imagn Images

Nov 9, 2024; Chestnut Hill, Massachusetts, USA; Syracuse Orange tight end Oronde Gadsden II (19) celebrates with wide receiver Trebor Pena (2) after scoring a touchdown against the Boston College Eagles during the first half at Alumni Stadium. Mandatory Credit: Brian Fluharty-Imagn Images

MATCHUP UConn Huskies Syracuse Orange
Team Records 1-1 1-1
Where JMA Wireless Dome, Syracuse, NY
When Saturday, September 6, 2025
Time 12:00 PM EDT

In this article, we will formulate a UConn vs Syracuse Prediction for this College Football Week 2 game on Saturday, September 6th at the Rice-Eccles Stadium. Let’s take a look at the prediction for this College Football matchup.

Syracuse Orange Preview

The Orange are coming off a 26-45 home defeat by Tennessee in their season opener. Syracuse outgained their opponents by 377-495 yards. They had 23/40 completed passes, 274 passing yards, 103 rushing yards, with turnovers being 1-2. The Orange went 5-14 in third down efficiency and had 4-30 penalties.

Steve Angeli had 23/40 passes, a team-high 274 passing yards and one touchdown but also threw one interception and lost one fumble. Yasin Willis added a team-high 91 rushing yards, while Dan Villari caught 5 passes for 55 yards. Defensively, David Reese had seven total tackles, all of them solo, while Syracuse did not record any sacks. The Orange did not have any interceptions in this game.

Connecticut Huskies Preview

The Huskies are coming off a 59-13 home victory over Central Connecticut in their season opener last week. UConn outgained their opponents by 681-257 yards. They had 27/38 completed passes, 388 passing yards, 293 rushing yards, with both teams being 0-0 in turnovers. The Huskies went 12-16 in third down efficiency and had 8-78 penalties.

Joe Fagnano had 18/25 passes, a team-high 260 passing yards and three touchdowns. Cam Edwards added a team-high 115 rushing yards, while Skyler Bell caught 4 passes for 135 yards. Defensively, Tyquan King had eight total tackles, five of them solo, while Bryun Parham had one sack. The Huskies did not have any interceptions in this game.

Why the Syracuse Orange will win

Why the Connecticut Huskies will win

Total Points Facts

Matchup/League Facts

UConn vs Syracuse Prediction

Syracuse won their only meetings against UConn last season by 31-24 at home, not covering the spread, as the game went over the point total. Syracuse has won their last five meetings against UConn, but the Huskies are 6-3-1 against the spread in their last 10 meetings. Over is 4-2 in their last 6 meetings.

In this UConn vs Syracuse Prediction, Syracuse is coming in as -7-point home favorites, with the total set at 58.5 points. Both teams are coming off opposite outcomes in their season openers, but the opposition was on a completely different level. The Huskies won an inferior team, but their offense looked great and both teams are coming off high scoring games, with 71 and 72 total points. Their last two meetings between those two teams have gone over the total, and UConn was 7-3-2 to the over last season. I expect another high-scoring affair today, so take the over 58.5 points in this one.

Nikos Lagouretos's Pick: Over 58.5

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