Indiana State vs Duke Prediction 11/14/2025 Today’s College Basketball Picks

The Indiana State Sycamores and the Duke Blue Devils meet Friday in college basketball action from Cameron Indoor Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Indiana State Sycamores vs. Duke Blue Devils prediction.

Indiana State Sycamores Recap

The Indiana State Sycamores come into this game looking to add on to their 64-55 win over SIU-Edwardsville to sit at 2-1 this season. After this game, Indiana State will head home for a game against Louisiana Tech.

Sycamores Win Back-To-Back Games

Ian Scott leads the Sycamores in scoring and rebounding with 14.3 PPG and 10 RPG while Sterling Young has 13 PPG with 1.7 SPG and Derek Vorst has 10.3 PPG with 4.7 RPG to cap off the trio of double-digit scorers for Indiana State so far this season. Markus Harding has averaged 9.3 PPG with 2.3 RPG and Camp Wagner has 9.3 PPG with 3.3 RPG as well on the year. As a team, Indiana State is averaging 81.3 PPG on 46.7% shooting from the field, 25.6% from three and 72.2% from the foul line this season.

Duke Blue Devils Recap

The Duke Blue Devils come into this game looking to add on to their 114-59 blowout win over Army last time out to sit at 3-0 this season. After this game, Duke will take on the Kansas Jayhawks.

Blue Devils Looking To Remain Unbeaten

Cameron Boozer leads the Blue Devils in scoring and rebounding with 18.3 PPG and 9.7 RPG along with 4 APG while Isaiah Evans has 15.7 PPG with 3.3 RPG. Patrick Ngongba II has 12 PPG with 6.7 RPG to cap off the trio of double-digit scorers for Duke so far this season. Dame Sarr has 9.7 PPG with 4.3 RPG and 2 SPG while Cayden Boozer has 8.7 PPG with 4 RPG and a team-high 5 APG to lead Duke in assists up to this point in the season. As a team, Duke is averaging 94.7 PPG on 49.2% shooting from the field, 38% from three and 77.2% from the foul line this season.

Indiana State Sycamores @ Duke Blue Devils Betting Trends: November 14, 2025

Why the Duke Blue Devils will win

• Duke has won each of its last 23 games at Cameron Indoor Stadium against non-AP-ranked opponents.
• Indiana State has lost 13 of its last 14 games against AP-ranked opponents.
• Duke has won the first half in each of its last 11 games against non-Conference opponents at Cameron Indoor Stadium.

Total Points Facts

• Each of Duke’s last 19 night games against non-Conference opponents at Cameron Indoor Stadium have produced a total of 162 or fewer points.
• Four of Indiana State’s last five games have produced a total of 168+ points.

Matchup/League Facts

• Duke is one of only four teams to reach the Elite 8 in each of its last two NCAA Tournament appearances.

Indiana State Sycamores vs. Duke Blue Devils Prediction

I’m on Duke here. It’s a massive line especially with Duke having Kansas on deck. However, Duke has shown no mercy to anyone this season, stepping all over anyone inferior in their path and just nearly doubled up Army at West Point. I think Duke relishes in these opportunities to get Cameron Indoor going nuts and I think they log another blowout win here. Give me Duke.

Chris Ruffolo's Pick: Duke -38.5