Aug 26, 2025; Milwaukee, Wisconsin, USA;  Milwaukee Brewers left fielder Isaac Collins (6) is dunked with Gatorade by  Andruw Monasterio (14) after driving in the winning run during the ninth inning against the Arizona Diamondbacks at American Family Field. Mandatory Credit: Jeff Hanisch-Imagn Images

Arizona Diamondbacks vs Milwaukee Brewers Prediction 8/27/2025 Today’s MLB Picks

Pick details

Arizona (64-69) vs Milwaukee (83-50)

August 27, 2025 at 07:40 PM EDT

The Line: Betting Odds: Milwaukee -1.5 — Over/Under: +8.5

(Get latest betting odds)

The Arizona Diamondbacks and Milwaukee Brewers meet Wednesday in MLB action at American Family Field. Here’s a Arizona Diamondbacks vs Milwaukee Brewers Prediction. This article will include a Arizona Diamondbacks vs Milwaukee Brewers Pick.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks are 64-69 on the year and play the Dodgers, Rangers, and Red Sox next. The Arizona Diamondbacks are batting .251 on the season, have a .324 OBP, and a .439 slugging percentage. The Arizona Diamondbacks pitching staff has a 4.58 ERA and a 1.33 WHIP. Geraldo Perdomo leads the Arizona Diamondbacks with 141 hits and 86 RBI, while Corbin Carroll and Lourdes Gurriel Jr. have combined for 239 hits and 147 RBI.

Ryne Nelson gets the ball for the Arizona Diamondbacks, and he is 6-3 with a 3.63 ERA and 105 strikeouts this season. Nelson is 1-0 with a 4.50 ERA and 9 strikeouts in his career against the Milwaukee Brewers.

Milwaukee Brewers Betting Preview

The Milwaukee Brewers are 83-50 on the year and play the Blue Jays, Phillies, and Pirates next. The Milwaukee Brewers are batting .258 on the season, have a .332 OBP, and a .406 slugging percentage. The Milwaukee Brewers pitching staff has a 3.62 ERA and a 1.23 WHIP. Brice Turang leads the Milwaukee Brewers with 136 hits and 67 RBI while Christian Yelich and Sal Frelick have combined for 259 hits and 141 RBI.

Quinn Priester gets the ball for the Milwaukee Brewers, and he is 11-2 with a 3.44 ERA and 104 strikeouts this season. Priester is 4-4 with a 3.59 ERA and 62 strikeouts in his career against the Arizona Diamondbacks.

Why the Milwaukee Brewers will win

  • The Brewers have won 15 of their last 16 night games at American Family Field following a home win.
  • The Diamondbacks have lost each of their last seven night games against the Brewers at American Family Field following a road loss.
  • The Diamondbacks have failed to cover the run line in nine of their last 11 games.
  • The Brewers have covered the run line in 10 of their last 12 night games against National League opponents following a home win.
  • The Brewers have led after 3 innings in five of their last six home night games.
  • The Diamondbacks have trailed after 5 innings in each of their last four games as road underdogs.

Why the Arizona Diamondbacks will win

  • The Diamondbacks have won each of their last eight Wednesday night games as road underdogs against NL Central opponents.
  • The Brewers have lost four of their last five games as favorites against the Diamondbacks following a win.
  • The Brewers have failed to cover the run line in each of their last seven games against the Diamondbacks following a home win.
  • The Diamondbacks have covered the run line in each of their last nine Wednesday night games as road underdogs against NL Central opponents.

Milwaukee Brewers Player Prop Facts

  • Brice Turang has recorded at least one hit in each of his last 12 appearances against NL West opponents.
  • Jackson Chourio has hit a home run in each of his last two appearances in night games against NL West teams that held a losing record.

Arizona Diamondbacks Player Prop Facts

  • Gabriel Moreno has hit a home run in three of his last five appearances in night games against NL Central teams that held a winning record.
  • Ryne Nelson has recorded six or more strikeouts in each of his last four appearances in night games against teams that held a winning record.
  • Corbin Carroll has recorded a Double in three of the Diamondbacks’ last four night games against NL Central opponents that held a winning record.
  • Corbin Carroll has recorded at least one hit in each of the Diamondbacks’ last 13 games against NL opponents.
  • Corbin Carroll ranks 5th amongst qualified players for Slugging Percentage (.554) this season.

Arizona Diamondbacks vs Milwaukee Brewers Prediction

The Diamondbacks are not having a great week, and Nelson has allowed 25 hits and 14 runs in his last 23.1 innings. In 55.2 road innings, Nelson has a 5.01 ERA and .224 allowed batting average. The Brewers have lost just seven games since July 27. That’s seven losses in the last month. The Brewers have won 15 straight games Priester has pitched. The Brewers haven’t lost with Priester on the mound since May 24. Not sure how you step in front of the Brewers in this spot.

Randy Chambers's Pick: Milwaukee Brewers

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