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Arizona Diamondbacks vs Minnesota Twins Prediction 9/12/2025 Today’s MLB Picks

Arizona Diamondbacks Jake McCarthy (31) bats against the Minnesota Twins in the fourth inning at Chase Field in Phoenix on Thursday, June 27, 2024.

Arizona Diamondbacks Jake McCarthy (31) bats against the Minnesota Twins in the fourth inning at Chase Field in Phoenix on Thursday, June 27, 2024.

MATCHUP Diamondbacks Arizona Twins Minnesota
Team Records 73-75 65-82
Where Target Field, Minneapolis, Minnesota
When Friday, September 12, 2025
Time 08:10 PM EDT
TV Twins.TV
In this article, we will formulate a Diamondbacks vs Twins Prediction for this MLB game on Friday, September 12th at the Target Field the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Minnesota Twins Preview

The Minnesota Twins have a 64-82 record this season and are sitting on the 4th place of the AL Central. The Twins have a 35-36 home record and are 69-68 in over/under. They are coming off a 3-4 road defeat by the Angels, and are 2-8 in their last 10 games. Over is 6-4 in their last 12 games and are playing the Yankees and the Guardians next.

The Twins have a .239 batting average this season, .312 OBP and .398 Slugging percentage. Minnesota’s pitching staff has a 4.60 ERA and 1.33 WHIP. Trevor Larnach leads the Twins with 119 hits, while Byron Buxton adds team-highs both in RBI, with 76, and in home runs, with 31. He is also the team’s best hitter with a .275 batting average.

Pablo Lopez (R) is the projected starter for the Twins, and he has a 5-4 record, 2.84 ERA and 1.08 WHIP.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 73-74 record this season and are sitting on the 4th place of the NL West. The Diamondbacks have a 34-40 road record and are 70-68 in over/under They are coming off a 5-11 road defeat by the Giants, and have back-to-back losses. Over is 3-1 in their last 4 games and are playing the Phillies and the Giants next.

The Diamondbacks have a .250 batting average this season, .323 OBP and .434 slugging percentage. Arizona’s pitching staff has a 4.47 ERA and 1.32 WHIP. Geraldo Perdomo leads the Diamondbacks with 153 hits, adding a team-high 93 RBI. He Is also the team’s best hitter with a .284 batting average, while Corbin Carroll leads the team in home runs with 29.

Brandon Pfaadt (R) is the projected starting pitcher for the Diamondbacks, and he has a 13-8 record, 5.18 ERA and 1.38 WHIP.

Arizona Diamondbacks @ Minnesota Twins Betting Trends: September 12, 2025


Why the Minnesota Twins will win


Why the Arizona Diamondbacks will win

Total Runs Facts

Minnesota Twins Player Prop Facts

Arizona Diamondbacks Player Prop Facts

Matchup/League Facts

Diamondbacks vs Twins Prediction

The Twins are 5-1 in their last 6 head-to-head meetings against the Diamondbacks, having won their last four meetings in Minnesota. Over is 4-1 in their last 5 meetings.

In this Diamondbacks vs Twins Prediction, the Twins are coming as -130 home favorites. I don’t trust either team in this spot, as the Twins are looking like they have given up on the season, while the Dbacks are putting Pfaadt on the mound, who has been shaky at best, and terrible on the road, with a 7.13 road ERA. Lopez look good in his first start after his injury, and the Twins have a slightly better bullpen. Take the better pitcher playing at home in this one, so take the Minnesota Twins on the moneyline.

Nikos Lagouretos's Pick: Minnesota Twins -126

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