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Arizona Diamondbacks vs San Diego Padres Prediction 9/27/2025 Today’s MLB Picks

Sep 26, 2025; San Diego, California, USA; San Diego Padres right fielder Fernando Tatis Jr. (23) celebrates with shortstop Xander Bogaerts (2) after defeating the Arizona Diamondbacks at Petco Park. Mandatory Credit: David Frerker-Imagn Images

Sep 26, 2025; San Diego, California, USA; San Diego Padres right fielder Fernando Tatis Jr. (23) celebrates with shortstop Xander Bogaerts (2) after defeating the Arizona Diamondbacks at Petco Park. Mandatory Credit: David Frerker-Imagn Images

MATCHUP Diamondbacks Arizona Padres San Diego
Team Records 80-81 89-72
Where Petco Park, San Diego, California
Time Sep 28th, 12:40 AM Z
TV MLB.TV

The Arizona Diamondbacks and San Diego Padres meet Saturday in MLB action at Petco Park. Here’s a Arizona Diamondbacks vs San Diego Padres Prediction. This article will include a Arizona Diamondbacks vs San Diego Padres Pick.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks are 80-80 on the year after playing the Dodgers. The Arizona Diamondbacks are batting .251 on the season, have a .325 OBP, and a .433 slugging percentage. The Arizona Diamondbacks pitching staff has a 4.44 ERA and a 1.32 WHIP. Geraldo Perdomo leads the Arizona Diamondbacks with 171 hits and 98 RBI while Corbin Carroll and Ketel Marte have combined for 281 hits and 155 RBI.

Eduardo Rodriguez gets the ball for the Arizona Diamondbacks, and he is 9-8 with a 4.91 ERA and 137 strikeouts this season. Rodriguez is 1-1 with a 2.30 ERA and 12 strikeouts in his career against the San Diego Padres.

San Diego Padres Betting Preview

The San Diego Padres are 88-72 on the year after playing the Brewers. The San Diego Padres are batting .252 on the season, have a .321 OBP, and a .388 slugging percentage. The San Diego Padres pitching staff has a 3.64 ERA and a 1.21 WHIP. Luis Arraez leads the San Diego Padres with 180 hits and 61 RBI while Manny Machado and Fernando Tatis Jr. have combined for 324 hits and 163 RBI.

Michael King gets the ball for the San Diego Padres, and he is 5-3 with a 3.57 ERA and 73 strikeouts this season. King is 2-0 with a 0.00 ERA and 8 strikeouts in his career against the Arizona Diamondbacks.

Arizona Diamondbacks @ San Diego Padres Betting Trends: September 27, 2025

Why the San Diego Padres will win

Why the Arizona Diamondbacks will win

Total Runs Facts

San Diego Padres Player Prop Facts

Arizona Diamondbacks Player Prop Facts

Matchup/League Facts

Arizona Diamondbacks vs San Diego Padres Prediction

The Diamondbacks have nothing to play for now that they’re out of the playoff race, and while Rodriguez has been improved this month, he has a 4.91 ERA and 1.56 WHIP on the season. In 76 road innings, Rodriguez has a 4.74 ERA and .294 allowed batting average. The Padres are heading into the playoffs on a hot streak and while King has been struggling in recent starts, he has a 3.57 ERA and 1.20 WHIP on the season. In 45.1 home innings, King has a 2.58 ERA and .193 allowed batting average. I’ll roll with the hot hand and side with the Padres.

Randy Chambers's Pick: San Diego Padres

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