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Arizona Diamondbacks vs San Francisco Giants Prediction 9/9/2025 Today’s MLB Picks

Sep 8, 2025; San Francisco, California, USA; San Francisco Giants center fielder Jung Hoo Lee (51) bunt hits to load the bases against the Arizona Diamondbacks during the sixth inning at Oracle Park. Mandatory Credit: Neville E. Guard-Imagn Images

Sep 8, 2025; San Francisco, California, USA; San Francisco Giants center fielder Jung Hoo Lee (51) bunt hits to load the bases against the Arizona Diamondbacks during the sixth inning at Oracle Park. Mandatory Credit: Neville E. Guard-Imagn Images

MATCHUP Diamondbacks Arizona Giants San Francisco
Team Records 72-74 73-71
Where Oracle Park, San Francisco, California
When Tuesday, September 9, 2025
Time 09:45 PM EDT
TV NBC Sports BA
In this article, we will formulate a Diamondbacks vs Giants Prediction for this MLB game on Tuesday, September 9th at the Oracle Park in the second game of this series, with the Giants having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

San Francisco Giants Preview

The San Francisco Giants have a 73-71 record this season and are sitting on the third place of the NL West. They have a 36-34 home record and are 68-70 in over/under. They are coming off a 11-5 home victory over the Giants, that ended their two-game losing streak. Over is 7-3 in their last 10 games and are playing the Dodgers and the Diamondbacks next.

The Giants have a .240 batting average this season, .314 OBP and .393 Slugging percentage. San Francisco’s pitching staff has a 3.75 ERA and 1.29 WHIP.  Heliot Ramos leads the Giants with 146 hits, while Jung Hoo Lee is the team’s best hitter, with a .271 batting average. Willy Adames leads the team in RBI with 78, adding a team-high 27 home runs. 

Robbie Ray (L) is the projected starting pitcher for the Giants, and he has a 10-6 record, 3.31 ERA and 1.18 WHIP.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 72-73 record this season and are sitting on the 4th place of the NL West. The Diamondbacks have a 34-39 road record and are 69-67 in over/under They are coming off a 5-11 road defeat by the Giants, and have back-to-back losses. Over is 3-1 in their last 4 games and are playing the Twins and the Giants next.

The Diamondbacks have a .250 batting average this season, .322 OBP and .435 slugging percentage. Arizona’s pitching staff has a 4.48 ERA and 1.32 WHIP. Geraldo Perdomo leads the Diamondbacks with 150 hits, adding a team-high 91 RBI. Ketel Marte is the team’s best hitter with a .287 batting average, while Corbin Carroll leads the team in home runs with 29.

Zac Gallen (R) is the projected starting pitcher for the Diamondbacks, and he has a 11-13 record, 4.77 ERA and 1.28 WHIP.

Arizona Diamondbacks @ San Francisco Giants Betting Trends: September 9, 2025

Why the San Francisco Giants will win

Why the Arizona Diamondbacks will win

Total Runs Facts

San Francisco Giants Player Prop Facts

Arizona Diamondbacks Player Prop Facts

Matchup/League Facts

Diamondbacks vs Giants Prediction

The Giants have won their last three head-to-head meetings against the Dbacks, but both teams are tied 2-2 wins in their last 4 meetings in San Francisco. Over is 8-2-1 in their last 11 meetings.

In this Diamondbacks vs Giants Prediction, the Giants are coming as -140 home favorites. Zach Gallen is looking like his former self in his last three starts, where he has back-to-back shutout starts and just one earned runs in his last 18 innings pitched. He has given up only one run in his previous start against the Giants this season, while on the flip side, Ray has been struggling for the Giants lately, having given up 13 runs in 13.3 innings pitched across his last three starts. I will take a stab with the road dog and hoping that Gallen continues to be hot on the mound for the Dbacks. Take the Arizona Diamondbacks and the plus money on the road.

Nikos Lagouretos's Pick: Arizona Diamondbacks +120

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