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Baltimore Orioles vs Chicago White Sox Prediction 9/15/2025 Today’s MLB Picks

Sep 14, 2025; Toronto, Ontario, CAN; Baltimore Orioles shortstop Gunnar Henderson (2) throws to first base against the Toronto Blue Jays during the third inning in their MLB game at Rogers Centre. Mandatory Credit: Kevin Sousa-Imagn Images

Sep 14, 2025; Toronto, Ontario, CAN; Baltimore Orioles shortstop Gunnar Henderson (2) throws to first base against the Toronto Blue Jays during the third inning in their MLB game at Rogers Centre. Mandatory Credit: Kevin Sousa-Imagn Images

MATCHUP Orioles Baltimore White Sox Chicago
Team Records 70-80 57-94
Where Rate Field, Chicago, Illinois
When Monday, September 15, 2025
Time 07:40 PM EDT
TV MAS+

The Baltimore Orioles and the Chicago White Sox meet Monday in MLB action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Baltimore Orioles vs. Chicago White Sox prediction.

Starting Pitching Matchup

The Baltimore Orioles will send out Kyle Bradish for hte start and Bradish is 0-1 with a 2.65 ERA and 21 strikeouts this season. This will be Bradish’s second career start against the White Sox. The Chicago White Sox did not have a starting pitcher announced at the time that this article was posted.

Baltimore Orioles Recap

The Baltimore Orioles come into this game looking to rebound from an 11-2 loss at the hands of the Toronto Blue Jays last time out to sit at 69-80 this season. After this series, the Orioles will head home for a series against the New York Yankees.

Orioles Drop Three Straight

Adley Rutschman has 70 hits with 16 doubles, 9 homers and 29 RBIs. Jackson Holliday has 138 hits with 20 doubles, 3 triples, 17 homers and 55 RBIs. Gunnar Henderson has 143 hits with 32 doubles, 5 triples, 16 home runs and 62 RBIs with 23 stolen bases and 128 strikeouts while Holliday has a team-high 130 strikeouts as well this season. 

Chicago White Sox Recap

The Chicago White Sox come into this game looking to bounce back from their 3-2 loss at the hands of the Cleveland Guardians on Sunday to drop to 57-93 this season. After this series, the White Sox will take on the San Diego Padres in an interleague series at home.

White Sox Lose Three In A Row

Lenyn Sosa has 126 hits including 18 doubles, 20 home runs and 68 RBIs. Andrew Benintendi has 100 hits including 16 doubles, 19 home runs, 60 RBIs and a .241 batting average while Miguel Vargas has 107 hits, 31 doubles, 14 home runs and 53 RBIs. Brooks Baldwin has also added 31 RBIs while Luis Robert Jr. has a team-high 33 stolen bases along with 53 RBIs so far this season. Chase Meidroth has added 108 hits with 13 stolen bases as well as 15 doubles this season.

Baltimore Orioles @ the Chicago White Sox Betting Trends: September 15, 2025

Why the Chicago White Sox will win

Why the Baltimore Orioles will win

Total Runs Facts

Chicago White Sox Player Prop Facts

Baltimore Orioles Player Prop Facts

Matchup/League Facts

Baltimore Orioles vs. Chicago White Sox Prediction

I’m on the Orioles here. I get the case to be made for either side in this game, but I do really like what I’ve seen from Kyle Bradish in his limited action since returning from injury. It would be nice to know who the White Sox are putting out here, but I feel like the Orioles’ offense in this spot has more upside and I think the Orioles get the job done here. Give me Baltimore in this one.

Chris Ruffolo's Pick: Baltimore -145

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