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Boston Red Sox vs Tampa Bay Rays Prediction 9/20/2025 Today’s MLB Picks

Sep 19, 2025; Tampa, Florida, USA;  Boston Red Sox third base Alex Bregman (2) hits a home run during the third inning against the Tampa Bay Rays at George M. Steinbrenner Field. Mandatory Credit: Kim Klement Neitzel-Imagn Images

Sep 19, 2025; Tampa, Florida, USA; Boston Red Sox third base Alex Bregman (2) hits a home run during the third inning against the Tampa Bay Rays at George M. Steinbrenner Field. Mandatory Credit: Kim Klement Neitzel-Imagn Images

MATCHUP Red Sox Boston Rays Tampa Bay
Team Records 85-70 75-80
Where George M. Steinbrenner Field, Tampa, Florida
When Saturday, September 20, 2025
Time 07:05 PM EDT
TV MLB.TV

In this article, we will formulate a Red Sox vs Rays Prediction for this MLB game on Saturday, September 20th at the George M. Steinbrenner Field in the second game of this series, with the Red Sox having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Tampa Bay Rays Preview

The Tampa Bay Rays have a 75-79 record this season and are sitting on the 4th place of the AL East. The Rays have a 40-39 home record and are 67-77 in over/under. They are coming off a 7-11 home defeat by the Red Sox, that ended their two-game winning streak. They are playing the Orioles and the Blue Jays next.

The Rays have a .252 batting average this season, .314 OBP and .404 slugging percentage. Tampa’s pitching staff has a 3.85 ERA and 1.21 WHIP.  Yandy Diaz leads the Rays with 170 hits, and he is the team’s best hitter with .300 batting average. Junior Caminero leads the team in RBI, with 108 and in home runs, with 44.

Adrian Houser (R) is the projected starting pitcher for the Rays, and he has an 8-4 record, 3.11 ERA and 1.27 WHIP.

Boston Red Sox Preview

The Boston Red Sox have an 84-70 record this season and are sitting on the third place of the AL East. The Red Sox have a 38-38 road record and are 73-77 in over/under. They are coming off a 11-7 road victory over the Rays, and are 3-5 in their last 8 games. They are 6-3-1 to the under in their last 10 games and are playing the Tigers and the Blue Jays next.

The Red Sox have a .254 batting average this season, .324 OBP and .424 slugging percentage. Boston’s pitching staff has a 3.75 ERA and 1.29 WHIP. Trevor Story leads the Red Sox with 154 hits, while is the team’s best hitter, with a .265 batting average. He also leads the team in RBI, with 94, adding a team-high 25 home runs.

Kyle Harrison (L) is the projected starting pitcher for the Red Sox, and he has a 1-1 record, 4.05 ERA and 1.24 WHIP.

Boston Red Sox @ Tampa Bay Rays Betting Trends: September 20, 2025

Why the Tampa Bay Rays will win

Why the Boston Red Sox will win

Total Runs Facts

Tampa Bay Rays Player Prop Facts

Boston Red Sox Player Prop Facts

Matchup/League Facts

Red Sox vs Rays Prediction

The Red Sox are 9-1 in their last 10 head-to-head meetings against the Rays, and are 3-1 in their last 4 visits in Tampa Bay. Under is 5-1-1 in their last 7 meetings.

In this Red Sox vs Rays Prediction, both teams are coming at a pickem price. I don’t trust either pitcher in this matchup, so I’m staying away from any side. Houser has been excellent at home for the Rays, with a 7-0 record and 2.54 ERA, while on the flip side, Harrisson has been struggling lately for the Red Sox, having 8 earned runs in his last two starts. I like the value with the home team in a bounce-back spot, so take the Tampa Bay Rays on the moneyline in this one.

Nikos Lagouretos's Pick: Tampa Bay Rays ML

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