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Boston Red Sox vs Toronto Blue Jays Prediction 9/23/2025 Today’s MLB Picks

Sep 20, 2025; Kansas City, Missouri, USA; Toronto Blue Jays first base Vladimir Guerrero Jr. (27) reacts to a play during the fourth inning against the Kansas City Royals at Kauffman Stadium. Mandatory Credit: William Purnell-Imagn Images

Sep 20, 2025; Kansas City, Missouri, USA; Toronto Blue Jays first base Vladimir Guerrero Jr. (27) reacts to a play during the fourth inning against the Kansas City Royals at Kauffman Stadium. Mandatory Credit: William Purnell-Imagn Images

MATCHUP Red Sox Boston Blue Jays Toronto
Team Records 86-71 90-67
Where Rogers Centre, Toronto, Ontario
When Tuesday, September 23, 2025
Time 07:07 PM EDT
TV MLB.TV

The Boston Red Sox and the Toronto Blue Jays meet Tuesday in MLB action from Rogers Centre. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Boston Red Sox vs. Toronto Blue Jays prediction.

Starting Pitching Matchup

The Boston Red Sox will send out Lucas Giolito here and Giolito is 10-4 with a 3.46 ERA and 118 strikeouts this season. In his last five starts against the Blue Jays, Giolito is 1-2 with a 4.60 ERA and 24 strikeouts. Kevin Gausman will get the start for the Blue Jays and is 10-10 with a 3.38 ERA and 177 strikeouts this season. In his last five starts against Boston, Gausman is 2-1 with a 2.93 ERA and 29 strikeouts. 

Boston Red Sox Recap

The Boston Red Sox come into this game looking to rebound from a 7-3 loss at the hands of the Tampa Bay Rays last time out to sit at 85-71 this season. After this series, the Red Sox will head home for a series against the Detroit Tigers.

Red Sox In Midst Of Final Playoff Push

Alex Bregman has 116 hits including 27 doubles along with 18 home runs and 62 RBIs this season. Trevor Story’s added 156 hits with 25 home runs, 95 RBIs and 31 stolen bases while Jarren Duran has 156 hits with 39 doubles, 13 triples, 16 home runs, 82 RBIs and a team-high 24 stolen bases. Roman Anthony’s added 75 hits with 18 doubles, 8 home runs and 32 RBIs while Wilyer Abreu has 22 home runs with 69 RBIs and 6 stolen bases and Ceddanne Rafaela has 16 homers, 31 doubles, 3 triples, 62 RBIs and 19 stolen bases this season.

Toronto Blue Jays Recap

The Toronto Blue Jays come into this game looking to add on to their 8-5 win over the Kansas City Royals last time out to sit at 90-66 this season. After this series, the Blue Jays will take on the Tampa Bay Rays in a series at home.

Blue Jays Snap Four-Game Skid

George Springer has 145 hits and Bo Bichette has 181 hits with Springer adding 30 home runs, a triple, 25 doubles and 80 RBIs while Bichette has 44 doubles, 18 home runs and 94 RBIs. Andres Gimenez has added 66 hits with 9 doubles and 7 home runs and 32 RBIs this season along with 12 stolen bases. Vladimir Guerrero Jr. also has 23 homers, 34 doubles and 83 RBIs while Springer also has a .305 batting average and 106 strikeouts up to this point in the year. Addison Barger’s chipped in 31 doubles with 20 home runs and 73 RBIs and Ernie Clement’s added 33 doubles as part of his 146 hits this season.

Boston Red Sox @ Toronto Blue Jays Betting Trends: September 23, 2025

Why the Toronto Blue Jays will win

Why the Boston Red Sox will win

Total Runs Facts

Toronto Blue Jays Player Prop Facts

Boston Red Sox Player Prop Facts

Boston Red Sox vs. Toronto Blue Jays Prediction

I’m on the Blue Jays here. I just think that the Blue Jays have the edge in starting pitching for this matchup because as profitable as Lucas Giolito’s been at times this year, he’s still had issues with consistency. Toronto needs a win to get closer to the division title, and Kevin Gausman’s been a really strong option for this Blue Jays rotation in his recent outings. I’ll side with Toronto.

Chris Ruffolo's Pick: Toronto -165

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