Chicago Cubs vs San Francisco Giants Prediction 8/27/2025 Today’s MLB Picks

The Chicago Cubs and the San Francisco Giants meet Wednesday in MLB action from Oracle Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago Cubs vs. San Francisco Giants prediction.

Starting Pitching Matchup

The Chicago Cubs will start Colin Rea here and Rea is 10-5 with a 3.96 ERA and 93 strikeouts this season. Carson Whisenhunt will get the start for the Giants here and is 1-1 with a 4.91 ERA and 13 strikeouts this season.

Chicago Cubs Recap

The Chicago Cubs come into this game looking to bounce back from their 5-2 loss at the hands of the Giants on Tuesday to fall to 76-56 this season. After this series, the Cubs will head on the road for a series against the Colorado Rockies.

Cubs Still 6-2 In Last 8

Ian Happ has 103 hits with 22 doubles, 16 home runs and 56 RBIs. Kyle Tucker has 121 hits including 22 doubles, 4 triples, 21 home runs and 69 RBIs while Seiya Suzuki also has 118 hits with 27 doubles and 27 home runs and 87 RBIs of his own. Pete Crow-Armstrong also has contributed 125 hits, 33 doubles, 4 triples, 28 home runs and 82 RBIs as well this season. Dansby Swanson has added 18 home runs and 58 RBIs, while also having 141 strikeouts and Suzuki has 142 strikeouts so far this season. Crow-Armstrong also has a team-high 30 stolen bases while Nico Hoerner has 23 stolen bases this season. Tucker’s also added 25 stolen bases while Michael Busch has also chipped in 19 doubles, 3 triples, 24 home runs and 74 RBIs this season.

Why the Chicago Cubs will win

• The Giants have lost 14 of their last 15 home games after playing the previous day.
• The Cubs have won each of their last six games against NL West opponents following a road loss.
• The Giants have failed to cover the run line in each of their last 11 home games against National League opponents after playing the previous day.
• The Cubs have covered the run line in nine of their last 10 games as road favorites following a road loss.

Chicago Cubs Player Prop Facts

• Ian Happ has recorded a Double in three of his last four appearances with the Cubs as favorites against NL opponents.
• Kyle Tucker has hit at least one home run in two of the Cubs’ last three night games against opponents that held a losing record.
• Seiya Suzuki has recorded at least one hit in each of his last 17 appearances in night games against NL West teams that held a losing record.
• Pete Crow-Armstrong ranks T8th in the league in Steals (31) this season.

San Francisco Giants Recap

The San Francisco Giants come into this one looking to add on to their win over the Cubs on Tuesday to improve to 64-68 this season. After this series, the Giants will take on the Baltimore Orioles in a series at home.

Giants Win Three Straight

Jung Hoo Lee has 122 hits including a team-high 29 doubles along with 10 triples, 7 home runs and 47 RBIs with 10 stolen bases while Heliot Ramos has 130 hits with 22 doubles, 15 home runs and 55 RBIs. Wilmer Flores also 13 home runs and 63 RBIs while Tyler Fitzgerald has 9 stolen bases as well on the year. Matt Chapman also has 80 hits with 16 home runs and 44 RBIs along with 15 doubles and Willy Adames has 108 hits with 18 doubles, 22 home runs and 65 RBIs of his own this season.

Why the San Francisco Giants will win

• The Giants have won five of their last six games as underdogs against NL Central opponents.
• The Cubs have lost four of their last five games as road favorites against National League opponents.
• The Cubs have failed to cover the run line in each of their last 16 Wednesday night games as favorites against NL West opponents.
• The Giants have covered the run line in each of their last six games as underdogs against NL Central opponents.

San Francisco Giants Player Prop Facts

• Matt Chapman has hit at least one home run in each of his last two appearances with the Giants as home underdogs against NL opponents.
• Dominic Smith has recorded at least one hit in each of his last 14 appearances in night games.

Total Runs Facts

• Seven of the Cubs’ last eight road games have gone UNDER the total runs line.
• Each of the Giants’ last three home games against NL Central opponents have gone UNDER the total runs line.

Chicago Cubs vs. San Francisco Giants Prediction

I’m going to roll with Chicago here. I just can’t see the Giants stringing wins together consistently long term and I just don’t see Whisenhunt as major league ready. The Cubs are still the better team in my opinion, so I’ll roll with the Cubs in this one.