Chicago Cubs vs San Francisco Giants Prediction 8/28/2025 Today’s MLB Picks

The Chicago Cubs and San Francisco Giants meet Thursday in MLB action at Oracle Park. Here’s a Chicago Cubs vs San Francisco Giants Prediction. This article will include a Chicago Cubs vs San Francisco Giants Pick.

Chicago Cubs Betting Preview

The Chicago Cubs are 76-57 on the year and play the Rockies, Braves, and Nationals next. The Chicago Cubs are batting .249 on the season, have a .327 OBP, and a .424 slugging percentage. The Chicago Cubs pitching staff has a 3.83 ERA and a 1.20 WHIP. Nico Hoerner leads the Chicago Cubs with 140 hits and 53 RBI, while Pete Crow-Armstrong and Kyle Tucker have combined for 251 hits and 151 RBI.

Shota Imanaga gets the ball for the Chicago Cubs, and he is 8-6 with a 3.03 ERA and 90 strikeouts this season. This will be Imanaga’s second career game against the San Francisco Giants.

San Francisco Giants Betting Preview

The San Francisco Giants are 65-68 on the year and play the Orioles, Rockies, and Cardinals next. The San Francisco Giants are batting .233 on the season, have a .309 OBP, and a .380 slugging percentage. The San Francisco Giants pitching staff has a 3.70 ERA and a 1.28 WHIP. Heliot Ramos leads the San Francisco Giants with 135 hits and 57 RBI while Jung Hoo Lee and Willy Adames have combined for 231 hits and 113 RBI.

Logan Webb gets the ball for the San Francisco Giants, and he is 12-9 with a 3.13 ERA and 180 strikeouts this season. Webb is 2-1 with a 4.05 ERA and 20 strikeouts in his career against the Chicago Cubs.

Why the San Francisco Giants will win

• The Cubs have lost seven of their last eight games at Oracle Park against teams that held a losing record.
• The Giants have won each of their last four games against the Cubs.
• The Giants have covered the run line in each of their last seven games against NL Central opponents.
• The Cubs have failed to cover the run line in each of their last five road games against NL West opponents.
• The Giants have led after 3 innings in four of their last five games against the Cubs at Oracle Park.
• The Cubs have trailed after 5 innings in four of their last five games as road underdogs against National League opponents.

Why the Chicago Cubs will win

• The Giants have lost eight of their last nine games as home favorites after playing the previous day.
• The underdogs have won each of the Giants’ last four games.
• The Giants have failed to cover the run line each of their last nine Thursday games against teams that held a winning record.
• The Cubs have covered the run line in 13 of their last 14 games as road underdogs against National League opponents following a road loss.
• The Cubs have led after 5 innings in four of their last five day games against the Giants.
• The Giants have trailed after 3 innings in three of their last four games as favorites against National League opponents.

San Francisco Giants Player Prop Facts

• Logan Webb has recorded six or more strikeouts in each of his last seven appearances with the Giants as home favorites against NL Central opponents.
• Logan Webb has recorded a win in three of his last four appearances against NL Central opponents.
• Rafael Devers has recorded at least one hit in each of his 11 previous appearances against the Cubs.
• Matt Chapman has hit a home run in each of the Giants’ last three games at Oracle Park against NL Central opponents that held a winning record.

Chicago Cubs Player Prop Facts

• Kyle Tucker has hit a home run in each of the Cubs’ last two games as underdogs against NL West opponents.
• Shota Imanaga has recorded five or more strikeouts in each of his last five appearances against NL opponents.
• Shota Imanaga has recorded a win in five of his last six appearances with the Cubs as road underdogs.
• Dansby Swanson has recorded at least one hit in each of the Cubs’ last nine road games against NL West opponents that held a losing record.
• Kyle Tucker ranks 10th amongst qualified players for On Base Percentage (.374) this season.

Chicago Cubs vs San Francisco Giants Prediction

The Cubs are always worth a look with one of the best young arms on the mound in Imanaga. However, I usually don’t bet against Webb at Oracle. In 82 starts at Oracle, Webb has a 2.77 ERA and 1.12 WHIP with 490 strikeouts in 519 innings. Webb is basically a Hall of Fame pitcher when he takes the mound at Oracle. This year, through 87.2 innings at Oracle, Webb has a 2.77 ERA and .254 allowed batting average with 94 strikeouts. The Giants are also having a hell of a week currently. Give me the Giants.