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Chicago White Sox vs Detroit Tigers Prediction 9/5/2025 Today’s MLB Picks

Sep 4, 2025; Minneapolis, Minnesota, USA; Chicago White Sox shortstop Colson Montgomery (12) hits a two-run home run against the Minnesota Twins in the ninth inning at Target Field. Mandatory Credit: Bruce Kluckhohn-Imagn Images

Sep 4, 2025; Minneapolis, Minnesota, USA; Chicago White Sox shortstop Colson Montgomery (12) hits a two-run home run against the Minnesota Twins in the ninth inning at Target Field. Mandatory Credit: Bruce Kluckhohn-Imagn Images

MATCHUP Chicago White Sox Detroit Tigers
Team Records 54-88 81-61
Where Comerica Park, Detroit, Michigan
When Friday, September 5, 2025
Time 06:40 PM EDT
TV CHSN

The Chicago White Sox and Detroit Tigers meet Friday in MLB action at Comerica Park. Here’s a Chicago White Sox vs Detroit Tigers Prediction. This article will include a Chicago White Sox vs Detroit Tigers Pick.

Chicago White Sox Betting Preview

The Chicago White Sox are 53-88 on the year and play the Rays, Guardians, and Orioles next. The Chicago White Sox are batting .235 on the season, have a .304 OBP, and a .378 slugging percentage. The Chicago White Sox pitching staff has a 4.23 ERA and a 1.37 WHIP. Lenyn Sosa leads the Chicago White Sox with 119 hits and 62 RBI, while Miguel Vargas and Chase Meidroth have combined for 200 hits and 73 RBI.

Shane Smith gets the ball for the Chicago White Sox, and he is 4-7 with a 3.81 ERA and 112 strikeouts this season. Smith is 1-0 with a 0.00 ERA and 11 strikeouts in his career against the Detroit Tigers.

Detroit Tigers Betting Preview

The Detroit Tigers are 81-60 on the year and play the Yankees, Marlins, and Guardians next. The Detroit Tigers are batting .251 on the season, have a .320 OBP, and a .422 slugging percentage. The Detroit Tigers pitching staff has a 3.89 ERA and a 1.24 WHIP. Riley Greene leads the Detroit Tigers with 141 hits and 103 RBI while Gleyber Torres and Spencer Torkelson have combined for 235 hits and 134 RBI.

Jack Flaherty gets the ball for the Detroit Tigers, and he is 7-13 with a 4.74 ERA and 169 strikeouts this season. Flaherty is 3-2 with a 3.45 ERA and 35 strikeouts in his career against the Chicago White Sox.

The Chicago White Sox @ Detroit Tigers Betting Trends: September 5, 2025

Why the Detroit Tigers will win

Why the Chicago White Sox will win

Total Runs Facts

Detroit Tigers Player Prop Facts

Chicago White Sox Player Prop Facts

Matchup/League Facts

Chicago White Sox vs Detroit Tigers Prediction

The White Sox are piling up the wins this week, and it makes them worth a look here as well with an all-star on the mound. Smith isn’t winning games much due to a lack of run support, but he’s allowed 19 hits and 10 runs in his last 33.2 innings. Flaherty hasn’t been himself lately, which includes allowing 35 hits and 20 earned runs in his last 32.2 innings. The Tigers have lost 5 of Flaherty’s last 6 starts. This winning stretch for the White Sox won’t last much longer, but I’ll take a stab with them for one more game.

Randy Chambers's Pick: Chicago White Sox

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