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Chicago White Sox vs Minnesota Twins Prediction 9/2/2025 Today’s MLB Picks

Sep 1, 2025; Minneapolis, Minnesota, USA; Minnesota Twins pinch runner DaShawn Keirsey (21) scores on a sacrifice fly against the Chicago White Sox in the sixth inning at Target Field. Mandatory Credit: Bruce Kluckhohn-Imagn Images

Sep 1, 2025; Minneapolis, Minnesota, USA; Minnesota Twins pinch runner DaShawn Keirsey (21) scores on a sacrifice fly against the Chicago White Sox in the sixth inning at Target Field. Mandatory Credit: Bruce Kluckhohn-Imagn Images

MATCHUP Chicago White Sox Minnesota Twins
Team Records 50-88 62-75
Where Target Field, Minneapolis, Minnesota
When Tuesday, September 2, 2025
Time 07:40 PM EDT
TV CHSN

In this article, we will formulate a White Sox vs Twins Prediction for this MLB game on Tuesday, September 2nd at the Target Field in the second game of this series, with the White Sox having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Minnesota Twins Preview

The Minnesota Twins have a 62-75 record this season and are sitting on the 4th place of the AL Central. The Twins have a 35-33 home record and are 64-64 in over/under. They are coming off a 5-6 home defeat by the White Sox, and are 3-6 in their last 9 games. Over is 10-1 in their last 11 games and are playing the Angels and the Royals next.

The Twins have a .238 batting average this season, .311 OBP and .397 Slugging percentage. Minnesota’s pitching staff has a 4.47 ERA and 1.32 WHIP. Byron Buxton leads the Twins with 109 hits, adding team-highs both in RBI, with 72, and in home runs, with 29. He is also the team’s best hitter with a .272 batting average.

Simeon Woods Richardson (R) is the projected starting pitcher for the Twins, and he has a 5-4 record, 4.59 ERA and 1.42 WHIP.

Chicago White Sox Preview

The Chicago White Sox have a 50-88 record this season and are sitting on the last place of the AL Central. The White Sox have a 20-46 road record and are 64-66 in over/under. They are coming off a 6-5 road victory over the Twins, and have back-to-back wins. Over is 5-2 in their last 7 games and are playing the Rays and the Tigers next.

The White Sox have a .234 batting average this season, .302 OBP and .374 Slugging percentage. Chicago’s pitching staff has a 4.23 ERA and 1.37 WHIP. Lenyn Sosa leads the White Sox with 117 hits, and he is the team’s best hitter with a .266 batting average. He also leads the team in RBI with 61, adding a team-high 18 home runs.

Davis Martin (R) is the projected starting pitcher for the White Sox, and he has a 5-9 record, 4.03 ERA and 1.28 WHIP.

Why the Minnesota Twins will win

Why the Chicago White Sox will win

Total Runs Facts

Matchup/League Facts

White Sox vs Twins Prediction

The White Sox are 4-1 in their last 5 head-to-head meetings against the Twins, but the Twins are 3-2 in their last 5 meetings in Minnesota. Over is 7-3-1 in their last 11 meetings.

In this White Sox vs Twins Prediction, the Twins are coming as -154 home favorites. I don’t trust either pitcher in this matchup, as Richardson has not been in the best form lately, with a 5.14 ERA across his last 5 starts, while Martin has been weaker on the road, with a 4.58 road ERA. Minnesota’s offense has been red-hot lately, with 5+ runs in five of their last six games, and both bullpens have 4.00+ ERA. Yesterday’s game had 11 total runs, and with both teams with nothing to play for, I expect another high-scoring affair. Take the over 9 runs.

Nikos Lagouretos's Pick: Over 9

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