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Chicago White Sox vs New York Yankees Prediction 9/23/2025 Today’s MLB Picks

Sep 21, 2025; Baltimore, Maryland, USA;  New York Yankees first base Ben Rice (22) celebrates with designated hitter Aaron Judge (99) at home plate after hitting a tenth inning grand slam against the Baltimore Orioles at Oriole Park at Camden Yards. Mandatory Credit: Tommy Gilligan-Imagn Images

Sep 21, 2025; Baltimore, Maryland, USA; New York Yankees first base Ben Rice (22) celebrates with designated hitter Aaron Judge (99) at home plate after hitting a tenth inning grand slam against the Baltimore Orioles at Oriole Park at Camden Yards. Mandatory Credit: Tommy Gilligan-Imagn Images

MATCHUP White Sox Chicago Yankees New York
Team Records 58-99 89-68
Where Yankee Stadium, Bronx, New York
When Tuesday, September 23, 2025
Time 07:05 PM EDT
TV MLB.TV

The Chicago White Sox and New York Yankees meet Tuesday in MLB action at Yankee Stadium. Here’s a Chicago White Sox vs New York Yankees Prediction. This article will include a Chicago White Sox vs New York Yankees Pick.

Chicago White Sox Betting Preview

The Chicago White Sox are 68-98 on the year and play the Nationals next. The Chicago White Sox are batting .232 on the season, have a .302 OBP, and a .372 slugging percentage. The Chicago White Sox pitching staff has a 4.23 ERA and a 1.36 WHIP. Lenyn Sosa leads the Chicago White Sox with 129 hits and 71 RBI, while Chase Meidroth and Miguel Vargas have combined for 223 hits and 80 RBI.

Shane Smith gets the ball for the Chicago White Sox, and he is 6-8 with a 4.06 ERA and 129 strikeouts this season. This will be Smith’s second career game against the New York Yankees.

New York Yankees Betting Preview

The New York Yankees are 88-68 on the year and play the Orioles next. The New York Yankees are batting .250 on the season, have a .330 OBP, and a .454 slugging percentage. The New York Yankees pitching staff has a 3.97 ERA and a 1.26 WHIP. Aaron Judge leads the New York Yankees with 170 hits and 105 RBI while Cody Bellinger and Paul Goldschmidt have combined for 286 hits and 141 RBI.

Luis Gil gets the ball for the New York Yankees, and he is 4-1 with a 3.33 ERA and 36 strikeouts this season. Gil is 1-1 with a 5.12 ERA and 29 strikeouts in his career against the Chicago White Sox.

The Chicago White Sox @ New York Yankees Betting Trends: September 23, 2025

Why the New York Yankees will win

Why the Chicago White Sox will win

Total Runs Facts

New York Yankees Player Prop Facts

Chicago White Sox Player Prop Facts

Chicago White Sox vs New York Yankees Prediction

Smith has been great this season, but it looks like he may have hit the rookie wall, allowing 19 hits and 12 runs in his last 21.1 innings. In 64.2 road innings, Smith has a 4.59 ERA and .238 allowed batting average, which is a drop from his home splits. The White Sox as a team recently look like, well, how the White Sox usually look. The Yankees are at home and two games out of the AL East. There are no excuses not to win this game and the series. I’ll roll with the Yankees on Tuesday night.

Randy Chambers's Pick: New York Yankees

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