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New York Mets vs Chicago Cubs Prediction 9/24/2025 Today’s MLB Picks

Aug 31, 2025; Denver, Colorado, USA; Chicago Cubs pitcher Matthew Boyd (16) delivers a pitch in the first inning against the Colorado Rockies at Coors Field. Mandatory Credit: Ron Chenoy-Imagn Images

Aug 31, 2025; Denver, Colorado, USA; Chicago Cubs pitcher Matthew Boyd (16) delivers a pitch in the first inning against the Colorado Rockies at Coors Field. Mandatory Credit: Ron Chenoy-Imagn Images

MATCHUP White Sox Chicago Yankees New York
Team Records 58-100 90-68
Where Yankee Stadium, Bronx, New York
When Wednesday, September 24, 2025
Time 07:05 PM EDT
TV MLB.TV

In this article, we will formulate a Mets vs Cubs Prediction for this MLB game on Wednesday, September 24th at the Wrigley Field in the second game of this series, with the Mets having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Chicago Cubs Preview

The Chicago Cubs have an 88-69 record this season and are sitting on the second place of the NL Central. The Cubs have a 46-30 home record and are 70-74 in over/under. They are coming off a 7-9 home defeat by the Mets, and have five straight defeats. They are playing the Cardinals next.

The Cubs have a .249 batting average this season, .320 OBP and .425 Slugging percentage. Chicago’s pitching staff has a 3.82 ERA and 1.19 WHIP. Nico Hoerner leads the Cubs with 174 hits, and he is the team’s best hitter with a .302 batting average. Seiya Suzuki leads the team in RBI, with 92, while Michael Busch adds a team-high 30 home runs.

Matthew Boyd (L) is the projected starting pitcher for the Cubs, and he has a 13-8 record, 3.20 ERA and 1.11 WHIP.

New York Mets Preview

The New York Mets have an 81-76 record this season and are sitting on the second place of the NL East. The Mets have a 32-44 road record and are 74-75 in over/under. They are coming off a 9-7 road victory over the Cubs, that ended their two-game losing streak. Over is 7-3 in their last 10 games and are playing the Marlins next.

The Mets have a .251 batting average this season, .327 OBP and .430 slugging percentage. New York’s pitching staff has a 4.00 ERA and 1.33 WHIP.  Francisco Lindor leads the Mets with 168 hits, while Pete Alonso leads the team in batting average with .273. He also adds a team-high 123 RBI, while Juan Soto adds team-high 42 home runs.

Jonah Tong (R) is the projected starting pitcher for the Mets, and he has a 2-2 record, 5.94 ERA and 1.44 WHIP.

New York Mets @ the Chicago Cubs Betting Trends: September 24, 2025

Why the Chicago Cubs will win

Why the New York Mets will win

Total Runs Facts

Chicago Cubs Player Prop Facts

New York Mets Player Prop Facts

Matchup/League Facts

Mets vs Cubs Prediction

The Mets are 4-1 in their last 5 head-to-head meetings against the Cubs, and are 3-1 in their last 4 meetings in Chicago. Over is 5-2-1 in their last 8 meetings.

In this Mets vs Cubs Prediction, the Cubs are coming as -125 home favorites. The Cubs have been struggling since clinching their playoff spot, while the Mets are still fighting for a wild card spot. The Cubs have the pitching advantage in this one, as Boyd takes the mound and he has been excellent this season, and even better at home, with a 2.45 ERA. On the flip side, Tong was torched in his two starts before his last shutout, having 10 earned runs in just 6.2 innings pitched. I like the hosts in a bounce-back spot today, so take the Cubs on the moneyline in this one.

Nikos Lagouretos's Pick: Chicago Cubs -125

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