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Cincinnati Reds vs Houston Astros Prediction 5/11/25 MLB Picks

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Houston Astros (19-19) vs Cincinnati Reds (20-21)

Game Info: Sunday, May 11, 2025 at 2:10 pm (Daikin Park)

The Line: Betting Odds: Houston Astros -155 / Cincinnati Reds +130 — Over/Under: 8.5

(Get latest betting odds)

The Cincinnati Reds and Houston Astros meet Sunday in MLB action at Daikin Park. Here’s a Cincinnati Reds vs Houston Astros Prediction. This article will include a Cincinnati Reds vs Houston Astros Pick.

Cincinnati Reds Betting Preview

The Cincinnati Reds are 20-21 on the year and play the White Sox, Guardians, and Pirates next. The Cincinnati Reds are batting .242 on the season, have a .325 OBP, and a .383 slugging percentage. The Cincinnati Reds pitching staff has a 3.71 ERA and a 1.16 WHIP. TJ Friedl leads the Cincinnati Reds with 43 hits and 17 RBI, while Elly De La Cruz and Gavin Lux have combined for 77 hits and 47 RBI. 

Chase Petty gets the ball for the Cincinnati Reds, and he is 0-1 with a 34.71 ERA and 3 strikeouts this season. This will be Petty’s first career game against the Houston Astros.

Houston Astros Betting Preview

The Houston Astros are 19-19 on the year and play the Royals, Rangers, and Rays next. The Houston Astros are batting .247 on the season, have a .318 OBP, and a .375 slugging percentage. The Houston Astros’ pitching staff has a 3.53 ERA and a 1.16 WHIP. Jeremy Pena leads the Houston Astros with 42 hits and 19 RBI, while Jose Altuve and Isaac Paredes have combined for 74 hits and 31 RBI.

Ronel Blanco gets the ball for the Houston Astros, and he is 2-3 with a 4.98 ERA and 32 strikeouts this season. This will be Blanco’s second career game against the Cincinnati Reds.

Why the Houston Astros will win

Why the Cincinnati Reds will win

Houston Astros Player Prop Facts

Cincinnati Reds Player Prop Facts

Cincinnati Reds vs Houston Astros Prediction

The Reds have had issues stringing together wins lately, and I’m not running to the window to back Petty, who has just 2.1 innings under his belt. Petty was rocked in his MLB debut against the Cardinals, allowing seven hits and nine runs while getting just one ground ball. The Astros and Blanco aren’t lighting the world on fire, as he’s allowed 30 hits and 19 runs in 34.1 innings. Still, we saw Blanco have a strong season last year, and he’s been solid at home this season, posting a 3.74 ERA and .173 allowed batting average in 21.2 innings. The Astros should win this game. Give me the home team and a reasonable price.

Randy Chambers's Pick: Houston Astros -155

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