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Cincinnati Reds vs San Diego Padres Prediction 9/9/2025 Today’s MLB Picks

Sep 8, 2025; San Diego, California, USA; San Diego Padres center fielder Jackson Merrill (3) hits an RBI triple during the sixth inning against the Cincinnati Reds at Petco Park. Mandatory Credit: Denis Poroy-Imagn Images

Sep 8, 2025; San Diego, California, USA; San Diego Padres center fielder Jackson Merrill (3) hits an RBI triple during the sixth inning against the Cincinnati Reds at Petco Park. Mandatory Credit: Denis Poroy-Imagn Images

MATCHUP Reds Cincinnati Padres San Diego
Team Records 73-72 79-66
Where Petco Park, San Diego, California
When Tuesday, September 9, 2025
Time 09:40 PM EDT
TV FanDuel SN OH

In this article, we will formulate a Reds vs Padres Prediction for this MLB game on Tuesday, September 9th at the PETCO Park in the second game of this series, with the Padres having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

San Diego Padres Preview

The San Diego Padres have a 79-65 record this season and are sitting on the second place of the NL West. They have a 44-25 home record, and are 61-77 in over/under. The Padres are coming off a 4-3 home victory over the Reds, and have three consecutive wins. Under is 3-1 in their last 4 games and are playing the Mets and the Rockies next. 

The Padres have a .252 batting average this season, .322 OBP and .387 Slugging percentage. San Diego’s pitching staff has a 3.66 ERA and 1.21 WHIP. Louis Arraez leads the Padres with 158 hits, and he is the team’s best hitter with a .283 batting average. Manny Machado leads the team both in RBI, with 84, and in home runs, with 23. 

Michael King (R) is the projected starting pitcher for the Padres, and he has a 4-2 record, 2.81 ERA and 1.09 WHIP.

Cincinnati Reds Preview

The Cincinnati Reds have a 72-72 record this season and are sitting in the third place of the NL Central. The Reds have a 32-38 road record and are 54-82 in over/under. They are coming off a 3-4 road defeat by the Padres, that ended their two-game winning streak. Under is 3-0-1 in their last 4 games and are playing the Cardinals and the Athletics next.

The Reds have a .247 batting average this season, .317 OBP and .392 slugging percentage. Cincinnati’s pitching staff has a 3.94 ERA and 1.25 WHIP.  Elly De La Cruz leads the Reds with 151 hits, and in RBI, with 81, adding a team-high 19 home runs. Gavin Lux is the team’s best hitter with a .268 batting average.

Zack Littell (R) is the projected starting pitcher for the Reds, and he has a 9-8 record, 3.81 ERA and 1.14 WHIP.

Cincinnati Reds @ San Diego Padres Betting Trends: September 9, 2025

Why the San Diego Padres will win

Why the Cincinnati Reds will win

Total Runs Facts

San Diego Padres Player Prop Facts

Cincinnati Reds Player Prop Facts

Matchup/League Facts

Reds vs Padres Prediction

The Padres are 4-2 in their last 6 head-to-head meetings against the Reds, and have won their last three meetings in San Diego. Over is 5-3-1 in their last 9 meetings.

In this Reds vs Padres Prediction, the Padres are coming as -190 home favorites. Kings takes the mound for the Padres and he is back after being a month in the IL. King has been elite this season and even better at home, with a 2.45 ERA, while on the flip side, Littell is coming into this matchup in poor form, having 11 earned runs in 14.1 innings pitched in his last three starts, having lost his last four starts. On top of that, San Diego has the best bullpen in baseball, so I expect them to dominate this game. Take the San Diego Padres and lay the juice at home.

Nikos Lagouretos's Pick: San Diego Padres -190

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