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Cleveland Guardians vs Tampa Bay Rays Prediction 9/7/2025 Today’s MLB Picks

Sep 5, 2025; St. Petersburg, Florida, USA; Cleveland Guardians left fielder Steven Kwan (38) hits a single in the sixth inning against the Tampa Bay Rays  at George M. Steinbrenner Field. Mandatory Credit: Jonathan Dyer-Imagn Images

Sep 5, 2025; St. Petersburg, Florida, USA; Cleveland Guardians left fielder Steven Kwan (38) hits a single in the sixth inning against the Tampa Bay Rays at George M. Steinbrenner Field. Mandatory Credit: Jonathan Dyer-Imagn Images

MATCHUP Guardians Cleveland Rays Tampa Bay
Team Records 72-70 71-72
Where George M. Steinbrenner Field, Tampa, Florida
When Sunday, September 7, 2025
Time 12:10 PM EDT
TV CLEGuardians.TV
In this article, we will formulate a Guardians vs Rays Prediction for this MLB game on Sunday, September 7th at the George M. Steinbrenner Field in the 4th game of this series, with the Guardians having the 2-1 lead. Let’s take a look at the prediction for this MLB matchup.

Tampa Bay Rays Preview

The Tampa Bay Rays have a 71-71 record this season and are sitting on the 4th place of the AL East. The Rays have a 38-35 home record and are 61-72 in over/under. They are coming off a 2-3 home defeat by the Guardians, and have back-to-back losses. Over is 5-2 in their last 7 games and are playing the Cubs and the White Sox next.

The Rays have a .252 batting average this season, .314 OBP and .403 slugging percentage. Tampa’s pitching staff has a 3.86 ERA and 1.21 WHIP.  Yandy Diaz leads the Rays with 154 hits, and he is the team’s best hitter with .293 batting average. Junior Caminero leads the team in RBI, with 103 and in home runs, with 41.

Drew Rasmussen (R) is the projected starting pitcher for the Rays, and he has a 10-5 record, 2.74 ERA and 0.97 WHIP.

Cleveland Guardians Preview

The Cleveland Guardians have a 71-70 record this season and are sitting on the third place of the AL Central. The Guardians have a 36-37 road record and are 66-70 in over/under. They are coming off a 3-2 road victory over the Rays, and are 3-1 in their last 4 games. Over is 4-2 in their last 6 games and are playing the Royals and the White Sox next.

The Guardians have a .224 batting average this season, .295 OBP and .368 Slugging percentage. Cleveland’s pitching staff has a 3.93 ERA and 1.32 WHIP. Stephen Kwan leads the Guardians with 149 hits, while Jose Ramirez is the team’s best hitter with a .283 batting average. He also leads the team both in RBI, with 73, and in home runs with 27.

Parker Messick (R) is the projected starting pitcher for the Guardians, and he has a 1-0 record, 2.08 ERA and 1.33 WHIP.


Cleveland Guardians @ Tampa Bay Rays Betting Trends: September 7, 2025


Why the Tampa Bay Rays will win


Why the Cleveland Guardians will win

Total Runs Facts

Tampa Bay Rays Player Prop Facts

Cleveland Guardians Player Prop Facts

Matchup/League Facts


Guardians vs Rays Prediction

The Guardians are 6-2 in their last 8 meetings against the Rays, and both teams are tied 3-3 wins in their last 6 meetings in Tampa. Under is 10-2-1 in their last 13 meetings.

In this Guardians vs Rays Prediction, the Rays are coming as -150 home favorites. The Rays were on a seven-game winning streak, before losing their last two games against the Guardians. Tampa have their ace on the mound in Drew Rasmussen, who has been elite this season, and he goes up against Parker Messick, who has only two starts for the Guardians, and I do no trust him in this spot. I like the hosts to bounce back after two straight home defeats, having their best pitcher on the mound. Take the Tampa Bay Rays on the moneyline at home in this one.

Nikos Lagouretos's Pick: Tampa Bay Rays -139

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