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Colorado Rockies vs San Francisco Giants Prediction 9/26/2025 Today’s MLB Picks

Sep 24, 2025; San Francisco, California, USA; San Francisco Giants catcher Andrew Knizner (21) rounds second base on his triple against the St. Louis Cardinals during the eighth inning at Oracle Park. Mandatory Credit: Neville E. Guard-Imagn Images

Sep 24, 2025; San Francisco, California, USA; San Francisco Giants catcher Andrew Knizner (21) rounds second base on his triple against the St. Louis Cardinals during the eighth inning at Oracle Park. Mandatory Credit: Neville E. Guard-Imagn Images

MATCHUP Rockies Colorado Giants San Francisco
Team Records 43-116 78-81
Where Oracle Park, San Francisco, California
Time Sep 27th, 2:15 AM Z
TV MLB.TV
The Colorado Rockies and San Francisco Giants meet Friday in MLB action at Oracle Park. Here’s a Colorado Rockies vs San Francisco Giants Prediction. This article will include a Colorado Rockies vs San Francisco Giants Pick.

Colorado Rockies Betting Preview


The Colorado Rockies are 43-116 on the year after playing the Mariners. The Colorado Rockies are batting .238 on the season, have a .294 OBP, and a .387 slugging percentage. The Colorado Rockies pitching staff has a 5.99 ERA and a 1.59 WHIP. Hunter Goodman leads the Colorado Rockies with 147 hits and 90 RBI while Jordan Beck and Mickey Moniak have combined for 255 hits and 120 RBI.

German Marquez gets the ball for the Colorado Rockies, and he is 3-15 with a 6.49 ERA and 82 strikeouts this season. Marquez is 5-11 with a 6.82 ERA and 93 strikeouts in his career against the San Francisco Giants.

San Francisco Giants Betting Preview


The San Francisco Giants are 78-81 on the year after playing the Cardinals. The San Francisco Giants are batting .235 on the season, have a .311 OBP, and a .385 slugging percentage. The San Francisco Giants pitching staff has a 3.88 ERA and a 1.31 WHIP. Heliot Ramos leads the San Francisco Giants with 157 hits and 66 RBI while Jung Hoo Lee and WIlly Adames have combined for 274 hits and 137 RBI.

Trevor McDonald gets the ball for the San Francisco Giants, and he is 0-0 with a 3.38 ERA and 4 strikeouts this season. This will be McDonald’s first career game against the Colorado Rockies.

Colorado Rockies @ San Francisco Giants Betting Trends: September 26, 2025


Why the San Francisco Giants will win

Why the Colorado Rockies will win

Total Runs Facts

San Francisco Giants Player Prop Facts

Colorado Rockies Player Prop Facts

Matchup/League Facts

Colorado Rockies vs San Francisco Giants Prediction


The Giants have nothing to play for now that they’ve been eliminated, and they haven’t won two straight games since September 9. McDonald also has just 11 MLB innings under his belt, so he’s not somebody I’m running to bet, given the small sample size. However, the Rockies are one of the worst teams in baseball history and are a club we’ve been fading all year. That doesn’t stop now. Marquez has been terrible this season, and that includes allowing 28 hits and 18 runs in his last 19.1 innings. No, thanks. Keep fading the Rockies until the season ends.

Randy Chambers's Pick: San Francisco Giants

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