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Detroit Tigers vs Boston Red Sox Prediction 9/26/2025 Today’s MLB Picks

Sep 25, 2025; Toronto, Ontario, CAN; Boston Red Sox third baseman Alex Bregman (2) throws out Toronto Blue Jays catcher Tyler Heineman (not pictured) at first base during the third inning at Rogers Centre. Mandatory Credit: John E. Sokolowski-Imagn Images

Sep 25, 2025; Toronto, Ontario, CAN; Boston Red Sox third baseman Alex Bregman (2) throws out Toronto Blue Jays catcher Tyler Heineman (not pictured) at first base during the third inning at Rogers Centre. Mandatory Credit: John E. Sokolowski-Imagn Images

MATCHUP Tigers Detroit Red Sox Boston
Team Records 86-74 88-72
Where Fenway Park, Boston, Massachusetts
Time Sep 26th, 11:10 PM Z
TV Apple TV+

The Detroit Tigers and the Boston Red Sox meet Friday in MLB action from Fenway Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Detroit Tigers vs. Boston Red Sox prediction.

Starting Pitching Matchup

The Detroit Tigers will send out Casey Mize for the start here and Mize is 14-6 with a 3.91 ERA and 131 strikeouts this season. In his career, Mize is 0-1 with a 4.29 ERA and 14 strikeouts against the Red Sox. The Boston Red Sox will trot out Kyle Harrison for the start here and Harrison is 1-1 with a 3.58 ERA and 32 strikeouts this season. This will be Harrison’s first career start against Detroit.

Detroit Tigers Recap

The Detroit Tigers come into this game looking to add on to their 4-2 win over Cleveland last time out to sit at 86-73 this season.

Tigers Snap 8-Game Losing Streak, Still Fighting For AL Central

Spencer Torkelson has 133 hits along with a .240 batting average including 31 home runs, 27 doubles and 78 RBIs. Kerry Carpenter also has 26 home runs and 62 RBIs while Riley Greene has 155 hits with 31 doubles, 36 home runs and 111 RBIs but also has a team-high 198 strikeouts as well this season. Dillon Dingler has 13 home runs and 57 RBIs and Zack McKinstry’s added 23 doubles, 11 triples, 12 home runs and 49 RBIs of his own along with 117 hits as well this season. Javier Baez has added 103 hits and 17 doubles as well as 11 home runs and 53 RBIs this season. Colt Keith also has 106 hits with 22 doubles, 13 home runs and 45 RBIs.

Boston Red Sox Recap

The Boston Red Sox come into this game looking to rebound from their 6-1 loss at the hands of the Toronto Blue Jays last time out to sit at 87-72 on the year. 

Red Sox Heading To Playoffs With Momentum

Alex Bregman has 117 hits including 27 doubles along with 18 home runs and 62 RBIs this season. Trevor Story’s added 161 hits with 25 home runs, 96 RBIs and 31 stolen bases while Jarren Duran has 157 hits with 40 doubles, 13 triples, 16 home runs, 82 RBIs and a team-high 24 stolen bases. Roman Anthony’s added 75 hits with 18 doubles, 8 home runs and 32 RBIs while Wilyer Abreu has 22 home runs with 69 RBIs and 6 stolen bases and Ceddanne Rafaela has 16 homers, 32 doubles, 3 triples, 62 RBIs and 19 stolen bases this season.

Detroit Tigers @ Boston Red Sox Betting Trends: September 26, 2025

Why the Boston Red Sox will win

Why the Detroit Tigers will win

Total Runs Facts

Boston Red Sox Player Prop Facts

Detroit Tigers Player Prop Facts

Matchup/League Facts

Detroit Tigers vs. Boston Red Sox Prediction

I’m on the Red Sox here. I get the case to be made for Detroit who has everything to fight for here as they’re not just at risk of losing the AL Central, but potentially falling out of the playoffs entirely. However, Casey Mize has been hittable and the Red Sox have been hitting righties well as of late, while the Tiers have not been good against lefties and while Kyle Harrison isn’t the most reliable of options, I think he’ll be good enough here to get the Red Sox the W. Give me Boston.

Chris Ruffolo's Pick: Boston -115

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