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Detroit Tigers vs Boston Red Sox Prediction 9/27/2025 Today’s MLB Picks

Detroit Tigers pitcher Tarik Skubal (29) throws against Cleveland Guardians during the first inning at Comerica Park in Detroit on Thursday, Sept. 18, 2025.

Detroit Tigers pitcher Tarik Skubal (29) throws against Cleveland Guardians during the first inning at Comerica Park in Detroit on Thursday, Sept. 18, 2025.

MATCHUP Tigers Detroit Red Sox Boston
Team Records 87-74 88-73
Where Fenway Park, Boston, Massachusetts
Time Sep 27th, 8:10 PM Z
TV MLB.TV

In this article, we will formulate a Tigers vs Red Sox Prediction for this MLB game on Saturday, September 27th at the Fenway Park in the second game of this series, with the Red Sox having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Boston Red Sox Preview

The Boston Red Sox have an 88-72 record this season and are sitting on the third place of the AL East. The Red Sox have a 47-32 home record and are 76-80 in over/under. They are coming off a 4-3 home victory over the Tigers, and are 3-1 in their last 4 games.

The Red Sox have a .255 batting average this season, .324 OBP and .422 slugging percentage. Boston’s pitching staff has a 3.72 ERA and 1.29 WHIP. Trevor Story leads the Red Sox with 161 hits, while is the team’s best hitter, with a .265 batting average. He also leads the team in RBI, with 96, adding a team-high 25 home runs.

Connelly Early (L) is the projected starting pitcher for the Red Sox, and he has a 1-1 record, 1.88 ERA and 1.12 WHIP.

Detroit Tigers Preview

The Detroit Tigers have an 86-74 record this season and are sitting on the first place of the AL Central. The Tigers have a 40-39 road record and are 83-69 in over/under. They are coming off a 3-4 road defeat by the Red Sox, and are 1-9 in their last 10 games. Under is 4-1 in their last 5 games.

The Tigers have a .247 batting average this season, .316 OBP and .415 slugging percentage. Detroit’s pitching staff has a 3.96 ERA and 1.25 WHIP. Riley Greene leads the Tigers with 155 hits, adding team-highs both in RBI, with 111, and in home runs, with 36. Zach McKinstry is the team’s best hitter with a .261 batting average.

Tarik Skubal (R) is the projected starter for the Tigers, and he has a 13-6 record, 2.21 ERA and 0.89 WHIP.

Detroit Tigers @ Boston Red Sox Betting Trends: September 27, 2025

Why the Boston Red Sox will win

Why the Detroit Tigers will win

Total Runs Facts

Boston Red Sox Player Prop Facts

Detroit Tigers Player Prop Facts

Matchup/League Facts

Tigers vs Red Sox Prediction

The Tigers are 5-1 in their last 6 meetings against the Red Sox, but the Red Sox are 3-2 in their last 5 meetings in Boston. Over is 7-3 in their last 10 meetings.  

The Tigers currently hold the third Wild Card spot of the AL, and need every win they can get in order to keep it secure. The Red Sox officially clinched their playoff spot with yesterday’s win and are putting a rookie on the mound today. On the flip side, the Tigers are putting Skubal on the mound for this crucial game, who has been in excellent form lately, having one earned run in each of his last two starts, and one earned run or less in six of his last seven starts. Take the Detroit Tigers to get the job done on the road in this one.

Nikos Lagouretos's Pick: Detroit Tigers ML

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