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Detroit Tigers vs Cleveland Guardians Prediction 9/24/2025 Today’s MLB Picks

Sep 23, 2025; Cleveland, Ohio, USA; Cleveland Guardians relief pitcher Hunter Gaddis (33) reacts at the end of the eighth inning against the Detroit Tigers at Progressive Field. Mandatory Credit: David Richard-Imagn Images

Sep 23, 2025; Cleveland, Ohio, USA; Cleveland Guardians relief pitcher Hunter Gaddis (33) reacts at the end of the eighth inning against the Detroit Tigers at Progressive Field. Mandatory Credit: David Richard-Imagn Images

MATCHUP Tigers Detroit Guardians Cleveland
Team Records 85-73 86-72
Where Progressive Field, Cleveland, Ohio
When Wednesday, September 24, 2025
Time 06:40 PM EDT
TV MLB.TV

The Detroit Tigers and Cleveland Guardians meet Wednesday in MLB action at Progressive Field. Here’s a Detroit Tigers vs Cleveland Guardians Prediction. This article will include a Detroit Tigers vs Cleveland Guardians Pick.

Detroit Tigers Betting Preview

The Detroit Tigers are 85-72 on the year and play the Red Sox next. The Detroit Tigers are batting .247 on the season, have a .316 OBP, and a .416 slugging percentage. The Detroit Tigers pitching staff has a 3.98 ERA and a 1.25 WHIP. Riley Greene leads the Detroit Tigers with 153 hits and 110 RBI, while Gleyber Torres and Spencer Torkelson have combined for 265 hits and 152 RBI.

Jack Flaherty gets the ball for the Detroit Tigers, and he is 8-14 with a 4.60 ERA and 182 strikeouts this season. Flaherty is 2-4 with a 2.21 ERA and 48 strikeouts in his career against the Cleveland Guardians.

Cleveland Guardians Betting Preview

The Cleveland Guardians are 85-72 on the year and play the Rangers next. The Cleveland Guardians are batting .226 on the season, have a .297 OBP, and a .373 slugging percentage. The Cleveland Guardians pitching staff has a 3.69 ERA and a 1.27 WHIP. Steven Kwan leads the Cleveland Guardians with 168 hits and 55 RBI while Jose Ramirez and Kyle Manzardo have combined for 269 hits and 150 RBI.

Tanner Bibee gets the ball for the Cleveland Guardians, and he is 11-11 with a 4.34 ERA and 157 strikeouts this season. Bibee is 3-3 with a 3.92 ERA and 43 strikeouts in his career against the Detroit Tigers.

Detroit Tigers @ Cleveland Guardians Betting Trends: September 24, 2025

Why the Cleveland Guardians will win

Why the Detroit Tigers will win

Total Runs Facts

Cleveland Guardians Player Prop Facts

Detroit Tigers Player Prop Facts

Matchup/League Facts

Detroit Tigers vs Cleveland Guardians Prediction

The Tigers have one win since September 11, and I doubt Flaherty is going to turn things around with his 4.60 ERA and 1.28 WHIP. In 64 road innings, Flaherty has a 5.20 ERA and .260 allowed batting average. The Guardians are one of the hotter teams in baseball with just 2 losses since September 5, and they now have a chance to win the AL Central. Bibee has allowed 11 hits and 3 runs in his last 21.2 innings. In 80.2 home innings, Bibee has a 3.35 ERA and .225 allowed batting average. Two teams heading in different directions. I have to side with the Guardians at home as they enter the driver’s seat for the division crown.

Randy Chambers's Pick: Cleveland Guardians

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