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Houston Astros vs Athletics Prediction 9/23/2025 Today’s MLB Picks

Sep 21, 2025; Houston, Texas, USA; Houston Astros relief pitcher Steven Okert (48) walks to the dugout after the Seattle Mariners defeated the Houston Astros at Daikin Park. Mandatory Credit: Thomas Shea-Imagn Images

Sep 21, 2025; Houston, Texas, USA; Houston Astros relief pitcher Steven Okert (48) walks to the dugout after the Seattle Mariners defeated the Houston Astros at Daikin Park. Mandatory Credit: Thomas Shea-Imagn Images

MATCHUP Astros Houston Athletics Oakland
Team Records 84-73 74-83
Where Sutter Health Park, Sacramento, California
When Tuesday, September 23, 2025
Time 10:05 PM EDT
TV MLB.TV

The Houston Astros and Athletics meet Tuesday in MLB action at Sutter Health Park. Here’s a Houston Astros vs Athletics Prediction. This article will include a Houston Astros vs Athletics Pick.

Houston Astros Betting Preview

The Houston Astros are 84-72 on the year and play the Angels next. The Houston Astros are batting .251 on the season, have a .316 OBP, and a .398 slugging percentage. The Houston Astros pitching staff has a 3.87 ERA and a 1.22 WHIP. Jose Altuve leads the Houston Astros with 152 hits and 75 RBI, while Jeremy Pena and Yainer Diaz have combined for 283 hits and 130 RBI.

Cristian Javier gets the ball for the Houston Astros, and he is 2-3 with a 4.45 ERA and 30 strikeouts this season. Javier is 4-4 with a 3.92 ERA and 68 strikeouts in his career against the Athletics.

Athletics Betting Preview

The Athletics are 73-83 on the year and play the Royals next. The Athletics are batting .253 on the season, have a .318 OBP, and a .432 slugging percentage. The Athletics pitching staff has a 4.72 ERA and a 1.36 WHIP. Brent Rooker leads the Athletics with 162 hits and 87 RBI while Tyler Soderstrom and Jacob Wilson have combined for 298 hits and 149 RBI.

Jeffrey Springs gets the ball for the Athletics, and he is 10-11 with a 4.17 ERA and 135 strikeouts this season. Springs is 2-0 with a 4.70 ERA and 7 strikeouts in his career against the Houston Astros.

Houston Astros @ Athletics Betting Trends: September 23, 2025

Why the Athletics will win

Why the Houston Astros will win

Total Runs Facts

Athletics Player Prop Facts

Houston Astros Player Prop Facts

Matchup/League Facts

Houston Astros vs Athletics Prediction

The Astros need to take advantage of games like this if they’re going to make the playoffs, but I’m looking at the over. Javier has allowed 17 hits and 10 runs in his last 16.1 innings, and he has a 7.88 ERA and .281 allowed batting average in 8 road innings. Springs has been hittable this season, especially at home through 77.1 innings where he has a 5.00 ERA and .254 allowed batting average. I expect some offense on Tuesday night. Give me the over.

Randy Chambers's Pick: Houston Astros

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