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Houston Astros vs Los Angeles Angels Prediction 9/27/2025 Today’s MLB Picks

Sep 26, 2025; Anaheim, California, USA; Los Angeles Angels outfielder Chris Taylor (33) catches the fly ball of Houston Astros pinch hitter Victor Caratini (17) during the eighth inning at Angel Stadium. Mandatory Credit: Gary A. Vasquez-Imagn Images

Sep 26, 2025; Anaheim, California, USA; Los Angeles Angels outfielder Chris Taylor (33) catches the fly ball of Houston Astros pinch hitter Victor Caratini (17) during the eighth inning at Angel Stadium. Mandatory Credit: Gary A. Vasquez-Imagn Images

MATCHUP Astros Houston Angels Los Angeles
Team Records 86-75 72-89
Where Angel Stadium, Anaheim, California
Time Sep 28th, 1:38 AM Z
TV MLB.TV

The Houston Astros and Los Angeles Angels meet Saturday in MLB action at Angel Stadium. Here’s a Houston Astros vs Los Angeles Angels Prediction. This article will include a Houston Astros vs Los Angeles Angels Pick.

Houston Astros Betting Preview

The Houston Astros are 85-75 on the year after playing the Athletics. The Houston Astros are batting .250 on the season, have a .315 OBP, and a .396 slugging percentage. The Houston Astros pitching staff has a 3.89 ERA and a 1.23 WHIP. Jose Altuve leads the Houston Astros with 155 hits and 77 RBI while Jeremy Pena and Christian Walker have combined for 286 hits and 147 RBI.

The Houston Astros didn’t announce a starting pitcher at the time the article was published.

Los Angeles Angels Betting Preview

The Los Angeles Angels are 72-88 on the year after playing the Royals. The Los Angeles Angels are batting .226 on the season, have a .298 OBP, and a .399 slugging percentage. The Los Angeles Angels pitching staff has a 4.87 ERA and a 1.43 WHIP. Taylor Ward leads the Los Angeles Angels with 131 hits and 103 RBI while Zach Neto and Nolan Schanuel have combined for 258 hits and 115 RBI.

Caden Dana gets the ball for the Los Angeles Angels, and he is 0-3 with a 6.39 ERA and 28 strikeouts this season. This will be Dana’s second career game against the Houston Astros.

Houston Astros @ Los Angeles Angels Betting Trends: September 27, 2025

Why the Los Angeles Angels will win

Why the Houston Astros will win

Total Runs Facts

Los Angeles Angels Player Prop Facts

Houston Astros Player Prop Facts

Matchup/League Facts

Houston Astros vs Los Angeles Angels Prediction

It’s hard to take the Astros seriously with the way they’re losing this week, but they’re still a veteran team that knows how to win this time of year. You’d think they can get the job done now to stay in the playoff race. The Angels haven’t won two straight games in 17 days, and Dana has allowed 18 hits and 13 earned runs in his last 19.1 innings. In 10.2 home innings, Dana has an 8.44 ERA and .286 allowed batting average. There are no excuses for the Astros. It’s win or go home. Give me the Astros.

Randy Chambers's Pick: Houston Astros

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