Los Angeles Angels vs San Diego Padres Prediction 5/14/25 MLB Picks

The Los Angeles Angels are visiting the San Diego Padres on Wednesday, May 14th at the PETCO Park in the second game of this series, with both teams being tied 1-1 wins. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Los Angeles Angels vs San Diego Padres Prediction. We will examine:

The San Diego Padres’ recent form and player performance

The Los Angeles Angels’ recent form and player performance

Recent betting trends and streaks involving the San Diego Padres

Recent betting trends and streaks involving the Los Angeles Angels

Recent betting trends in games played between the Los Angeles Angels vs San Diego Padres

A summary that ties it all together and produces a favorable betting outcome for the Los Angeles Angels vs San Diego Padres game

San Diego Padres Preview

The San Diego Padres have a 26-15 record this season and are sitting in second place in the NL West. They have a 15-5 home record and are 19-21 in over/under. The Padres are coming off a 6-4 home victory over the Angels, ending their previous two-game losing streak. Their last five game have gone over the total, and they are playing the Mariners and the Blue Jays next. 

The Padres have a .265 batting average this season, a .333 OBP, and a .401 Slugging percentage. San Diego’s pitching staff has a 3.38 ERA and 1.18 WHIP.  Manny Machado leads the Padres with 50 hits and a team-high .331 batting average. Fernando Tatis Jr leads the team both in RBI, with 26, and in home runs, with 11. 

Randy Vasquez (R) will take the mound for the Padres, and he has a 2-3 record, 3.76 ERA, and 1.59 WHIP. He has been better at home, with a 2.30 ERA across three home starts. He is coming off two good starts, having given up 3 runs across 11 innings of work, as the Padres won both games. This will be his first start against the Angels in his career.

Los Angeles Angels Preview

The Los Angeles Angels have a 17-24 record this season and are sitting in last place in the AL West. The Angels have an 8-14 road record and 24-17 in over/under. They are coming off a 4-6 road defeat by the Padres, and are 1-10 in their last 11 road games. Over is 9-3 in their last 12 games, and they are playing the Dodgers and the Athletics next.

The Angels have a .216 batting average this season, a .276 OBP, and a .389 Slugging percentage. LA’s pitching staff has a 5.13 ERA and 1.49 WHIP. Nolan Schanuel leads the Angels with 36 hits, and he is the team’s best hitter with a .265 batting average. Taylor Ward leads the team with 21 RBI.

Kyle Hendricks (R) will take the mound for the Angels, and he has a 1-4 record, 5.30 ERA, and 1.26 WHIP. He has been terrible on the road, with a 7.00 ERA across four road starts. He has been struggling lately, having given up 3+ runs in four of his last five starts. He has given up 3+ runs in four of his last five starts, and in his only start against the Padres last season, he got shelled with 7 earned runs across 5 innings of work.

Why the San Diego Padres will win

• The Padres have won each of their last 10 games as home favorites following a win.
• The Angels have lost each of their last seven road games following a road loss.
• The Padres have covered the run line in each of their last 11 home games following a win.
• The Angels have failed to cover the run line in each of their last seven road games following a road loss.
• The Angels have trailed after 3 innings in eight of their last nine road games.
• The Angels have trailed after 5 innings in each of their last nine road games against NL West opponents that held a winning record.

Why the Los Angeles Angels will win

• The Angels have won each of their last seven games as underdogs against NL West opponents following a loss.
• The Padres have lost five of their last six games as favorites against American League opponents.
• The Angels have covered the run line in each of their last seven games as underdogs against NL West opponents following a loss.
• The Padres have failed to cover the run line in seven of their last eight night games against American League opponents that held a losing record.
• The Angels have led after 3 innings in four of their last five night games against opponents that held a winning record.
• The Angels have won the first inning in three of their last four games.

Total Runs Facts

• Each of the Angels’ last six road games against National League opponents have gone OVER the total runs line.
• Seven of the Padres’ last eight games as favorites have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Padres’ last eight games against American League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Angels’ last six games.

Matchup/League Facts

• The Padres rank 1st in the league for batting average this season (.265).
• The Padres rank 1st in the league for strikeouts against this season (278).
• The Angels rank 30th in the league for on-base percentage this season (.276).
• The Angels rank 30th in the league for walks this season (99).

Los Angeles Angels vs San Diego Padres Prediction

The Angels are 4-1 in their last four meetings against the Padres, and under is 4-2 in their last 6 meetings. In this Los Angeles Angels vs San Diego Padres Prediction, the Padres are coming as -185 home favorites. The Padres are rightfully favored, as they have been the better team this season and the second-best home team in the National League, while the Angels are struggling on the road.

Vasquez’s deeper analytics show that he is due for regression, as he has an expected ERA of 5.98, and Hedricks for the Angels has been a dumpster fire, with terrible road performances and having been torched by the Padres last season. The Angels are tied for the worst bullpen in the MLB, with a 7.07 ERA and 1.73 WHIP, and both teams are very good at hitting righties, as they average 9.4 runs combined against right-handed pitching. Take the over 8.5 runs in this one.

Nikos Lagouretos's Pick: Over 8.5