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Los Angeles Dodgers vs San Francisco Giants Prediction 9/12/2025 Today’s MLB Picks

Sep 10, 2025; Los Angeles, California, USA; Los Angeles Dodgers designated hitter Shohei Ohtani (17) looks on during the first inning against the Colorado Rockies at Dodger Stadium. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images

Sep 10, 2025; Los Angeles, California, USA; Los Angeles Dodgers designated hitter Shohei Ohtani (17) looks on during the first inning against the Colorado Rockies at Dodger Stadium. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images

MATCHUP Dodgers Los Angeles Giants San Francisco
Team Records 82-65 75-72
Where Oracle Park, San Francisco, California
When Friday, September 12, 2025
Time 10:15 PM EDT
TV Sportsnet LA

The Los Angeles Dodgers and the San Francisco Giants meet Friday in MLB action from Oracle Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Los Angeles Dodgers vs. San Francisco Giants prediction.

Starting Pitching Matchup

The Los Angeles Dodgers will send out Yoshinobu Yamamoto here and Yamamoto is 11-8 with a 2.72 ERA and 177 strikeouts this season. In his career, Yamamoto is 0-1 with a 4.67 ERA and 17 strikeouts against the Giants. Justin Verlander will get the start for the Giants and is 3-10 with a 4.09 ERA and 120 strikeouts this season. In his career, Verlander is 3-1 with a 3.38 ERA and 33 strikeouts against the Dodgers.

Los Angeles Dodgers Recap

The Los Angeles Dodgers come into this game looking to add on to their 9-0 win over the Colorado Rockies last time out to sit at 82-64 this season. After this series, the Dodgers will head home for a series against the Philadelphia Phillies.

Dodgers Win Four In A Row

Shohei Ohtani has 152 hits including 21 doubles, 48 home runs, 90 RBIs and 8 triples . Michael Conforto has 73 hits with 20 doubles while Teoscar Hernandez has 107 hits with 21 home runs, 25 doubles and 78 RBIs as well this season. Ohtani has a team-high 17 stolen bases while Max Muncy has 10 doubles but also has 73 strikeouts so far this season. Mookie Betts has also chipped in 16 home runs and 67 RBIs as well on the year. Freddie Freeman has also logged 144 hits with a team-high 37 doubles, 19 home runs and 78 RBIs. Andy Pages also has 139 hits with 22 doubles, 24 home runs and 79 RBIs as well this season.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to bounce back from a 5-3 loss at the hands of the Arizona Diamondbacks last time out to sit at 74-72 on the year. After this series, the Giants will head on the road for a rematch series against the Diamondbacks. 

Giants Looking To Rebound After Failing To Complete Sweep

Jung Hoo Lee has 139 hits including a team-high 30 doubles along with 11 triples, 8 home runs and 51 RBIs with 10 stolen bases while Heliot Ramos has 146 hits with 23 doubles, 17 home runs and 61 RBIs. Wilmer Flores also 15 home runs and 67 RBIs while Tyler Fitzgerald has 9 stolen bases as well on the year. Matt Chapman also has 96 hits with 21 home runs and 56 RBIs along with 19 doubles and Willy Adames has 122 hits with 19 doubles, 28 home runs and 81 RBIs of his own this season. 

Los Angeles Dodgers @ San Francisco Giants Betting Trends: September 12, 2025

Why the San Francisco Giants will win

Why the Los Angeles Dodgers will win

Total Runs Facts

San Francisco Giants Player Prop Facts

Los Angeles Dodgers Player Prop Facts

Matchup/League Facts

Los Angeles Dodgers vs. San Francisco Giants Prediction

I’m leaning towards the Dodgers here. I just think that the Dodgers get it done here, because as well as Justin Verlander has pitched, the Giants have still had a hard time winning games with him on the mound. Yamamoto’s on a roll right now and I just don’t feel like stepping in front of him here. Give me the Dodgers in this one.

Chris Ruffolo's Pick: Los Angeles Dodgers -150

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