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Milwaukee Brewers vs Pittsburgh Pirates Prediction 9/6/2025 Today’s MLB Picks

Sep 5, 2025; Pittsburgh, Pennsylvania, USA;  Milwaukee Brewers catcher William Contreras (24) slides behind Pittsburgh Pirates catcher Joey Bart (14) to score a run during the ninth inning at PNC Park. Mandatory Credit: Charles LeClaire-Imagn Images

Sep 5, 2025; Pittsburgh, Pennsylvania, USA; Milwaukee Brewers catcher William Contreras (24) slides behind Pittsburgh Pirates catcher Joey Bart (14) to score a run during the ninth inning at PNC Park. Mandatory Credit: Charles LeClaire-Imagn Images

MATCHUP Brewers Milwaukee Pirates Pittsburgh
Team Records 88-55 64-79
Where PNC Park, Pittsburgh, Pennsylvania
When Saturday, September 6, 2025
Time 06:40 PM EDT
TV FanDuel SN WI

The Milwaukee Brewers and Pittsburgh Pirates meet Saturday in MLB action at PNC Park. Here’s a Milwaukee Brewers vs Pittsburgh Pirates Prediction. This article will include a Milwaukee Brewers vs Pittsburgh Pirates Pick.

Milwaukee Brewers Betting Preview

The Milwaukee Brewers are 87-55 on the year and play the Rangers, Cardinals, and Angels next. The Milwaukee Brewers are batting .259 on the season, have a .332 OBP, and a .407 slugging percentage. The Milwaukee Brewers pitching staff has a 3.62 ERA and a 1.24 WHIP. Brice Turang leads the Milwaukee Brewers with 149 hits and 71 RBI, while Sal Frelick and William Contreras have combined for 274 hits and 123 RBI.

Brandon Woodruff gets the ball for the Milwaukee Brewers, and he is 5-2 with a 3.69 ERA and 66 strikeouts this season. Woodruff is 7-3 with a 3.25 ERA and 107 strikeouts in his career against the Pittsburgh Pirates.

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 64-78 on the year and play the Orioles, Nationals, and Cubs next. The Pittsburgh Pirates are batting .234 on the season, have a .307 OBP, and a .352 slugging percentage. The Pittsburgh Pirates pitching staff has a 3.87 ERA and a 1.22 WHIP. Bryan Reynolds leads the Pittsburgh Pirates with 127 hits and 70 RBI while Andrew McCutchen and Tommy Pham have combined for 194 hits and 101 RBI.

Mitch Keller gets the ball for the Pittsburgh Pirates, and he is 6-13 with a 4.21 ERA and 132 strikeouts this season. Keller is 1-6 with a 5.59 ERA and 65 strikeouts in his career against the Milwaukee Brewers.

Milwaukee Brewers @ Pittsburgh Pirates Betting Trends: September 6, 2025

Why the Pittsburgh Pirates will win

Why the Milwaukee Brewers will win

Total Runs Facts

Pittsburgh Pirates Player Prop Facts

Milwaukee Brewers Player Prop Facts

Matchup/League Facts

Milwaukee Brewers vs Pittsburgh Pirates Prediction

The Brewers continue to win games and aren’t a team I’m excited to bet against. Woodruff has been solid this season as well in limited frames, and he’s allowing a .198 batting average in 26.2 road innings. The Pirates aren’t good, and Keller is coming off an August where he allowed 35 hits and 21 earned runs in 29 innings. Keller has also had zero success against the Brewers, which includes allowing a .333 batting average and .386 on base percentage in 117 at bats against current hitters. Give me the Brewers yet again.

Randy Chambers's Pick: Milwaukee Brewers

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