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Minnesota Twins vs Philadelphia Phillies Prediction 9/26/2025 Today’s MLB Picks

Jul 6, 2025; Minneapolis, Minnesota, USA; Minnesota Twins starting pitcher Joe Ryan (41) throws to the Tampa Bay Rays in the first inning at Target Field. Mandatory Credit: Bruce Kluckhohn-Imagn Images

Jul 6, 2025; Minneapolis, Minnesota, USA; Minnesota Twins starting pitcher Joe Ryan (41) throws to the Tampa Bay Rays in the first inning at Target Field. Mandatory Credit: Bruce Kluckhohn-Imagn Images

MATCHUP Twins Minnesota Phillies Philadelphia
Team Records 69-91 95-65
Where Citizens Bank Park, Philadelphia, Pennsylvania
Time Sep 26th, 10:45 PM Z
TV MLB.TV

In this article, we will formulate a Twins vs Phillies Prediction for this MLB game on Friday, September 26th at the Citizens Bank Park in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Philadelphia Phillies Preview

The Philadelphia Phillies have a 94-65 record this season and are sitting on the first place of the NL East. They have a 53-25 home record, and are 72-77 in over/under. They are coming off a 1-0 home victory over the Marlins, and have back-to-back wins. Over is 3-1 in their last 4 games.

The Phillies have a .260 batting average this season, .330 OBP and .434 Slugging percentage. Philly’s pitching staff has a 3.82 ERA and 1.24 WHIP. Trea Turner leads the Phillies with 179 hits and he is the team’s best hitter, with a .305 batting average. Kyle Schwarber leads the team with 132 RBI and a team-high 56 home runs.

Aaron Nola (R) is the projected starting pitcher for the Phillies, and he has a 4-10 record, 6.46 ERA and 1.45 WHIP.

Minnesota Twins Preview

The Minnesota Twins have a 69-90 record this season and are sitting on the 4th place of the AL Central. The Twins have a 31-47 road record and are 73-76 in over/under. They are coming off a 4-0 road victory over the Rangers, and are 3-1 in their last 4 game. Under is 6-0 in their last 5 games.

The Twins have a .239 batting average this season, .311 OBP and .397 Slugging percentage. Minnesota’s pitching staff has a 4.62 ERA and 1.32 WHIP. Byron Buxton leads the Twins with 127 hits, adding team-highs both in RBI, with 82, and in home runs, with 34. He is also the team’s best hitter with a .265 batting average.

Joe Ryan (R) is the projected starter for the Twins, and he has a 13-9 record, 3.47 ERA and 1.04 WHIP.

Minnesota Twins @ Philadelphia Phillies Betting Trends: September 26, 2025

Why the Philadelphia Phillies will win

Why the Minnesota Twins will win

Total Runs Facts

Philadelphia Phillies Player Prop Facts

Minnesota Twins Player Prop Facts

Matchup/League Facts

Twins vs Phillies Prediction

The Twins are 4-1 in their last 5 head-to-head meetings against the Phillies, and are 3-2 in their last 6 meetings in Philly.

In this Twins vs Phillies Prediction, the Phillies are coming as -170 home favorites. Both teams have nothing to play for, and the Twins are coming off a series win against the Rangers, and are putting their best pitcher on the mound in Joe Ryan. He goes up against Aaron Nola, who has been terrible this season, and he is coming into this matchup in terrible form, having given up 4+ runs in four of his last five starts. I like the Twins to keep this one close, so take them by +1.5 runs in this one.

Nikos Lagouretos's Pick: Minnesota Twins +1.5

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