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Oakland Athletics vs Pittsburgh Pirates Prediction 9/19/2025 Today’s MLB Picks

Sep 12, 2025; Washington, District of Columbia, USA; Pittsburgh Pirates starting pitcher Mitch Keller (23) pitches against the Washington Nationals during the first inning at Nationals Park. Mandatory Credit: Geoff Burke-Imagn Images

Sep 12, 2025; Washington, District of Columbia, USA; Pittsburgh Pirates starting pitcher Mitch Keller (23) pitches against the Washington Nationals during the first inning at Nationals Park. Mandatory Credit: Geoff Burke-Imagn Images

MATCHUP Athletics Oakland Pirates Pittsburgh
Team Records 73-81 65-89
Where PNC Park, Pittsburgh, Pennsylvania
When Friday, September 19, 2025
Time 06:40 PM EDT
TV MLB.TV

In this article, we will formulate an Athletics vs Pirates Prediction for this MLB game on Friday, September 19th at the PNC Park in the opening game of this series, with both teams being tied 1-1 wins. Let’s take a look at the prediction for this MLB matchup.

Pittsburgh Pirates Preview

The Pittsburgh Pirates have a 65-88 record this season and are sitting on the last place of the NL Central. They have a 42-36 home record, and are 61-87 in over/under. They are coming off a 4-8 home defeat by the Cubs, and are 1-10 in their last 11 games. Under is 7-3 in their last 10 games are playing the Reds and the Braves next.

The Pirates have a .230 batting average this season, .304 OBP and .347 slugging percentage. Pittsburgh’s pitching staff has a 3.87 ERA and 1.23 WHIP. Bryan Reynolds leads the Pirates with 134 hits, and a team-high 71 RBI. He is also the team’s best hitter with a .241 batting average, while Oneil Cruz leads the team in home runs, with 19.

Mitch Keller (R) is the projected starting pitcher for the Pirates, and he has a 6-14 record, 4.13 ERA and 1.25 WHIP.

Athletics Preview

The Athletics have a 72-81 record this season and are sitting on the last place of the AL West. The Athletics have a 39-39 road record and are 75-71 in over/under. They are coming off a 11-5 home victory over the Reds, and have three straight wins. Under is 7-3 in their last 10 games and are playing the Astros and the Royals next.

The Athletics have a .255 batting average this season, .321 OBP and .435 Slugging percentage. Athletics’ pitching staff has a 4.72 ERA and 1.36 WHIP. Brent Rooker leads the Athletics with 160 hits, while Jacob Wilson is the team’s best hitter with a .320 batting average. Tyler Soderstrom adds a team-high 90 RBI, while Nick Kurtz adds a team-high 32 home runs. 

Luis Severino (R) is the projected starter for the Athletics, and he has a 6-11 record, 4.82 ERA, and 1.32 WHIP.

Athletics @ Pittsburgh Pirates Betting Trends: September 19, 2025

Why the Pittsburgh Pirates will win

Why the Athletics will win

Total Runs Facts

Pittsburgh Pirates Player Prop Facts

Athletics Player Prop Facts

Matchup/League Facts

Athletics vs Pirates Prediction

The A’s have won their last 5 meetings against the Pirates, but the Pirates are 3-2 in their last 5 meetings in Pittsburgh. Under is 5-2-3 in their last 10 meetings.

In this Athletics vs Pirates Prediction, both teams are coming at a pickem price. I don’t trust either pitching in this matchup, as both have been shaky at best this season. Severino has 8 earned runs in his last two starts for the A’s, while Keller has at least two earned runs in his last four home starts. Both bullpens are terrible and both offenses are slightly better against right-handed pitching, so I like this game to go over the 8.5 total.

Nikos Lagouretos's Pick: Over 8.5

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