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Oakland Athletics vs Pittsburgh Pirates Prediction 9/21/2025 Today’s MLB Picks

Sep 20, 2025; Pittsburgh, Pennsylvania, USA;  Athletics shortstop Jacob Wilson (5) hits a double against the Pittsburgh Pirates during the second inning at PNC Park. Mandatory Credit: Charles LeClaire-Imagn Images

Sep 20, 2025; Pittsburgh, Pennsylvania, USA; Athletics shortstop Jacob Wilson (5) hits a double against the Pittsburgh Pirates during the second inning at PNC Park. Mandatory Credit: Charles LeClaire-Imagn Images

MATCHUP Athletics Oakland Pirates Pittsburgh
Team Records 73-83 67-89
Where PNC Park, Pittsburgh, Pennsylvania
When Sunday, September 21, 2025
Time 01:35 PM EDT
TV MLB.TV
In this article, we will formulate an Athletics vs Pirates Prediction for this MLB game on Sunday, September 21th at the PNC Park in the third game of this series, with both teams being tied 1-1 wins. Let’s take a look at the prediction for this MLB matchup.

Pittsburgh Pirates Preview

The Pittsburgh Pirates have a 66-89 record this season and are sitting on the last place of the NL Central. They have a 43-37 home record, and are 61-89 in over/under. They are coming off a 2-0 home victory over the A’s, that ended their five-game losing streak. Under is 9-3 in their last 12 games are playing the Reds and the Braves next.

The Pirates have a .230 batting average this season, .304 OBP and .347 slugging percentage. Pittsburgh’s pitching staff has a 3.85 ERA and 1.22 WHIP. Bryan Reynolds leads the Pirates with 137 hits, and a team-high 73 RBI. He is also the team’s best hitter with a .243 batting average, while Oneil Cruz leads the team in home runs, with 19.

Mike Burrows (R) is the projected starting pitcher for the Pirates, and he has a 2-4 record, 4.10 ERA and 1.24 WHIP.

Athletics Preview

The Athletics have a 73-82 record this season and are sitting on the last place of the AL West. The Athletics have a 40-40 road record and are 75-73 in over/under. They are coming off a 0-2 road defeat by the Pirates, that ended their four-game winning streak. Under is 9-3 in their last 12 games and are playing the Astros and the Royals next.

The Athletics have a .253 batting average this season, .319 OBP and .433 Slugging percentage. Athletics’ pitching staff has a 4.68 ERA and 1.36 WHIP. Brent Rooker leads the Athletics with 160 hits, while Jacob Wilson is the team’s best hitter with a .318 batting average. Tyler Soderstrom adds a team-high 90 RBI, while Nick Kurtz adds a team-high 33 home runs. 

Mitch Spence (R) is the projected starter for the Athletics, and he has a 3-5 record, 4.48 ERA, and 1.33 WHIP.

Athletics @ Pittsburgh Pirates Betting Trends: September 21, 2025


Why the Pittsburgh Pirates will win


Why the Athletics will win

Total Runs Facts

Pittsburgh Pirates Player Prop Facts

Athletics Player Prop Facts

Matchup/League Facts

Athletics vs Pirates Prediction

The A’s are 6-1 in their last 7 meetings against the Pirates, and are 3-1 in their last 4 meetings in Pittsburgh. Under is 7-2-3 in their last 12 meetings.

In this Athletics vs Pirates Prediction, the Pirates are coming as -115 home favorites. Both starting pitchers are coming into this matchup in completely opposite forms, as Burrows for the Pirates has one earned runs or less in three of his last four starts. On the flip side, Spence has been torched lately for the A’s, with 18 earned runs across his last four starts. The Pirates have a better bullpen to back Burrows, and I expect them to get away with another home win in this one.

Nikos Lagouretos's Pick: Pittsburgh Pirates -115

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