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Philadelphia Phillies vs Arizona Diamondbacks Prediction 9/19/2025 Today’s MLB Picks

May 4, 2025; Philadelphia, Pennsylvania, USA; Philadelphia Phillies first base Bryce Harper (3) reacts after hitting a flying out to center during the tenth inning against the Arizona Diamondbacks at Citizens Bank Park. Mandatory Credit: Eric Hartline-Imagn Images

May 4, 2025; Philadelphia, Pennsylvania, USA; Philadelphia Phillies first base Bryce Harper (3) reacts after hitting a flying out to center during the tenth inning against the Arizona Diamondbacks at Citizens Bank Park. Mandatory Credit: Eric Hartline-Imagn Images

MATCHUP Phillies Philadelphia Diamondbacks Arizona
Team Records 92-62 77-77
Where Chase Field, Phoenix, Arizona
When Friday, September 19, 2025
Time 09:40 PM EDT
TV MLBN

In this article, we will formulate a Phillies vs Diamondbacks Prediction for this MLB game on Friday, September 19th at the Chase Field in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 77-76 record this season and are sitting on the third place of the NL West. The Diamondbacks have a 40-35 home record and are 73-71 in over/under They are coming off a 1-5 home defeat by the Giants, which ended their four-game winning streak. They are playing the Padres and the Dodgers next.

The Diamondbacks have a .251 batting average this season, .324 OBP and .434 slugging percentage. Arizona’s pitching staff has a 4.44 ERA and 1.31 WHIP. Geraldo Perdomo leads the Diamondbacks with 162 hits, adding a team-high 97 RBI. He Is also the team’s best hitter with a .289 batting average, while Corbin Carroll leads the team in home runs with 30.

Ryne Nelson (R) is the projected starting pitcher for the Diamondbacks, and he has a 7-3 record, 3.34 ERA and 1.06 WHIP.

Philadelphia Phillies Preview

The Philadelphia Phillies have a 91-62 record this season and are sitting on the first place of the NL East. They have a 40-38 road record, and are 68-75 in over/under. They are coming off a 3-2 home victory over the Braves, and have three consecutive wins. Under is 3-1 in their last 4 games and are playing the Twins and the Marlins next.

The Phillies have a .259 batting average this season, .330 OBP and .431 Slugging percentage. Philly’s pitching staff has a 3.86 ERA and 1.24 WHIP. Trea Turner leads the Phillies with 179 hits and he is the team’s best hitter, with a .305 batting average. Kyle Schwarber leads the team with 128 RBI and a team-high 53 home runs.

Taijuan Walker (R) is the projected starting pitcher for the Phillies, and he has a 5-8 record, 4.17 ERA and 1.39 WHIP.

Philadelphia Phillies @ Arizona Diamondbacks Betting Trends: September 19, 2025

Why the Arizona Diamondbacks will win

Why the Philadelphia Phillies will win

Total Runs Facts

Arizona Diamondbacks Player Prop Facts

Philadelphia Phillies Player Prop Facts

Matchup/League Facts

Phillies vs Diamondbacks Prediction

The Diamondbacks are 4-2 in their last 6 head-to-head meetings against the Phillies, and have won their last three meetings in Arizona.

In this Phillies vs Diamondbacks Prediction, the Diamondbacks are coming as -125 home favorites. The Phillies are the better team, but recently clinched their playoff spot, while the Dbacks are still fighting for a Wild Card spot in the NL. Nelson has been a better pitching option than Walker, and he has been excellent at home, with a 2.51 ERA. He has one earned run or less in three of his last four starts, while on the flip side, Walker has been struggling for the Phillies lately, with an atrocious 7.20 ERA across his last 5 starts. The Dbacks need this win and they have the pitching advantage, so take them to win this one at home.

Nikos Lagouretos's Pick: Arizona Diamondbacks -125

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