Philadelphia Phillies vs Arizona Diamondbacks Prediction 9/21/2025 Today’s MLB Picks

In this article, we will formulate a Phillies vs Diamondbacks Prediction for this MLB game on Sunday, September 21st at the Chase Field in the third game of this series, with both teams being tied 1-1 wins. Let’s take a look at the prediction for this MLB matchup.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 78-77 record this season and are sitting on the third place of the NL West. The Diamondbacks have a 41-36 home record and are 74-72 in over/under They are coming off a 4-3 home victory over the Phillies, that ended their two-game losing streak. They are playing the Padres and the Dodgers next.

The Diamondbacks have a .251 batting average this season, .324 OBP and .434 slugging percentage. Arizona’s pitching staff has a 4.45 ERA and 1.31 WHIP. Geraldo Perdomo leads the Diamondbacks with 164 hits, adding a team-high 97 RBI. He Is also the team’s best hitter with a .289 batting average, and leads the team in home runs with 31.

Eduardo Rodriguez (L) is the projected starting pitcher for the Diamondbacks, and he has an 8-8 record, 5.12 ERA and 1.56 WHIP.

Philadelphia Phillies Preview

The Philadelphia Phillies have a 92-63 record this season and are sitting on the first place of the NL East. They have a 41-39 road record, and are 69-76 in over/under. They are coming off a 3-4 road defeat by the Dbacks, that ended their four-game winning streak. They are playing the Twins and the Marlins next.

The Phillies have a .260 batting average this season, .330 OBP and .432 Slugging percentage. Philly’s pitching staff has a 3.85 ERA and 1.24 WHIP. Trea Turner leads the Phillies with 179 hits and he is the team’s best hitter, with a .305 batting average. Kyle Schwarber leads the team with 129 RBI and a team-high 53 home runs.

Ranger Suarez (L) is the projected starting pitcher for the Phillies, and he has a 12-6 record, 2.84 ERA and 1.17 WHIP.

Philadelphia Phillies @ Arizona Diamondbacks Betting Trends: September 21, 2025

• Probable Starting Pitcher: Eduardo Rodriguez      Record this season: 8-8      ERA: 5.12
• Home Record: 2-2
• Last 5 against Phillies: 1-1

Why the Arizona Diamondbacks will win

• The Diamondbacks have won each of their last four games as home underdogs.
• The Phillies have lost 10 of their last 15 games as road favorites against National League opponents.
• The Diamondbacks have covered the run line in each of their last 11 games as underdogs following a win.
• The Phillies have failed to cover the run line in each of their last six Sunday games as road favorites against NL West opponents.
• The Diamondbacks have led after 5 innings in each of their last six games as home underdogs against National League opponents.
• The Diamondbacks have won the first inning in 10 of their last 11 home games against National League opponents that held a winning record.
• The Phillies have trailed after 3 innings in each of their last four games at Chase Field against opponents that held a winning record.

• Probable Starting Pitcher: Ranger Suarez      Record this season: 12-6      ERA: 2.84
• Road Record: 6-4
• Last 5 against Diamondbacks: 0-1

Why the Philadelphia Phillies will win

• The Phillies have won each of their last six games following a loss.
• The Diamondbacks have lost each of their last four home games against NL East opponents following a win.
• The Phillies have covered the run line in each of their last six games following a loss.
• The Diamondbacks have failed to cover the run line in 10 of their last 11 day games against NL East opponents following a home win.
• The Phillies have led after 5 innings in eight of their last 10 games as favorites against NL West opponents.
• The Phillies have won the first inning in three of their last four games as favorites against the Diamondbacks.

Total Runs Facts

• Each of the Phillies’ last six games as favorites have gone OVER the total runs line.
• Five of the Diamondbacks’ last six games against NL East opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Phillies’ last 10 games as favorites.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in 15 of the Diamondbacks’ last 16 home games against National League opponents.

Arizona Diamondbacks Player Prop Facts

• Corbin Carroll has hit at least one home run in six of the Diamondbacks’ last 10 home games against NL East opponents that held a winning record.
• Geraldo Perdomo has recorded a Double in four of the Diamondbacks’ last five games.
• Eduardo Rodriguez has recorded a win in four of his last five appearances with the Diamondbacks as underdogs.
• Eduardo Rodriguez has recorded six or more strikeouts in each of his four previous appearances against the Phillies.
• Geraldo Perdomo has recorded at least one hit in each of the Diamondbacks’ last 17 home games against NL opponents.
• Geraldo Perdomo ranks 5th amongst qualified players for On Base Percentage (.391) this season.

Philadelphia Phillies Player Prop Facts

• Kyle Schwarber has hit a home run in each of the Phillies’ last two games as favorites.
• J.T. Realmuto has recorded a Double in each of the Phillies’ last four day games against NL West opponents that held a winning record.
• Ranger Suarez has recorded a win in three of his last four appearances with the Phillies as favorites.
• Ranger Suarez has recorded six or more strikeouts in each of his last four appearances against the Diamondbacks.
• Trea Turner has recorded at least one hit in each of his last 15 road appearances.
• Kyle Schwarber ranks T2nd in the league in Home Runs (53) this season.

Matchup/League Facts

• The Diamondbacks rank 1st in the league for triples this season (37).
• The Diamondbacks rank 3rd in the league for RBIs this season (743).
• The Phillies rank 2nd in the league for walks allowed this season (421).
• The Phillies rank 3rd in the league for hits this season (1370).

Phillies vs Diamondbacks Prediction

The Phillies are 3-2 in their last 5 head-to-head meetings against the Diamondbacks, but the Dbacks are 4-1 in their last 5 meetings in Arizona.

In this Phillies vs Diamondbacks Prediction, the Phillies are coming as -135 road favorites. The Phillies have a huge pitching advantage in this game, as they are putting Suarez on the mound, who has been elite this season, and even better on the road, with a 2.25 ERA. On the flip side, Rodriguez has been terrible for the Dbacks, and even weaker at home, with a 5.56 ERA. Suarez has been lights out lately, having won his last 5 starts, with a 1.20 ERA in that span, while the Dbacks have the league’s third-worst bullpen ERA. Take the Philadelphia Phillies to getb the job done on the road in a reasonable price in this one.

Nikos Lagouretos's Pick: Philadelphia Phillies -135