San Diego Padres vs Colorado Rockies Prediction 9/6/2025 Today’s MLB Picks

In this article, we will formulate a Padres vs Rockies Prediction for this MLB game on Saturday, September 6th at the Coors Field in the second game of this series, with the Rockies having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Colorado Rockies Preview

The Colorado Rockies have a 40-101 record this season and are sitting on the last place of the NL West. The Rockies have a 23-50 home record and are 61-76 in over/under. They are coming off a 3-0 home victory over the Padres, which ended their three-game losing streak. They are playing the Dodgers and the Padres next.

The Rockies have a .241 batting average this season, .298 OBP and .393 Slugging percentage. Colorado’s pitching staff has a 5.97 ERA and 1.60 WHIP. Hunter Goodman leads the Rockies with 132 hits, also leading the team both in RBI, with 85, and in home runs, with 28. He is also the team’s best hitter with a .285 batting average.

McCade Brown (R) is the projected starting pitcher for the Rockies, and he has a 0-2 record, 8.22 ERA and 2.09 WHIP.

San Diego Padres Preview

The San Diego Padres have a 76-65 record this season and are sitting on the second place of the NL West. They have a 33-40 road record, and are 60-75 in over/under. The Padres are coming off a 0-3 road defeat by the Rockies, and are 1-7 in their last 8 games. Over is 7-2-2 in their last 11 games and are playing the Reds and the Rockies next. 

The Padres have a .251 batting average this season, .321 OBP and .384 Slugging percentage. San Diego’s pitching staff has a 3.66 ERA and 1.21 WHIP. Louis Arraez leads the Padres with 155 hits, and he is the team’s best hitter with a .284 batting average. Manny Machado leads the team both in RBI, with 81, and in home runs, with 22. 

Randy Vasquez (R) is the projected starting pitcher for the Padres, and he has a 3-6 record, 3.96 ERA and 1.38 WHIP.

Why the Colorado Rockies will win

• The Padres have lost each of their last four games as favorites.
• The underdogs have won five of the Padres’ last seven games.
• The Padres have failed to cover the run line in each of their last five games.
• The underdogs have covered the run line in each of the Padres’ last four games.
• The Padres have trailed after 3 innings in each of their last four road games against NL West opponents.
• The Padres have trailed after 5 innings in each of their last 10 road games.

Why the San Diego Padres will win

• The Rockies have lost each of their last seven night games after playing the previous day.
• The Padres have won each of their last five road games against the Rockies following a road loss.
• The Padres have covered the run line in each of their last five road games against the Rockies following a road loss.
• The Rockies have failed to cover the run line in each of their last four games following a win.
• The Padres have won the first inning in three of their last four night games against the Rockies.
• The Rockies have trailed after 5 innings in each of their last seven Saturday night games against opponents that held a winning record.
• The Rockies have trailed after 3 innings in four of their last five games against NL West opponents.

Total Runs Facts

• Ten of the Padres’ last 11 night games against NL West opponents have gone UNDER the total runs line.
• Three of the last four games between the Padres and Rockies have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Rockies’ last eight Saturday night games against NL West opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Padres’ last five road games.

Matchup/League Facts

• The Rockies rank 1st in the league for triples this season (35).
• The Rockies rank 30th in the league for walks this season (351).
• The Padres rank 1st in the league for opponent batting average this season (.225).
• The Padres rank 1st in the league for hits allowed this season (1041).

Padres vs Rockies Prediction

The Padres are 5-2 in their last 7 head-to-head meetings against the Rockies, but the Rockies are 4-3 in their last 7 meetings in Colorado. Over is 3-1 in their last 4 meetings.

In this Padres vs Rockies Prediction, the Padres are coming as -190 road favorites. The Padres are on a free fall lately, and I cannot back them up as big road favorites with Vasquez on the mound, who has been weaker on the road, with a 4.17 road ERA. On the flip side, McCade Brown looked terrible in his two starts for the Rockies, who also have one of the league’s weakest bullpens. Both teams are hitting better against righties, and I like both offenses to bounce back today. Take the over 12 runs.

Nikos Lagouretos's Pick: Over 12