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San Diego Padres vs New York Mets Prediction 9/16/2025 Today’s MLB Picks

Jul 30, 2025; San Diego, California, USA; San Diego Padres relief pitcher Robert Suarez (75) throws a pitch during the ninth inning against the New York Mets at Petco Park. Mandatory Credit: David Frerker-Imagn Images

Jul 30, 2025; San Diego, California, USA; San Diego Padres relief pitcher Robert Suarez (75) throws a pitch during the ninth inning against the New York Mets at Petco Park. Mandatory Credit: David Frerker-Imagn Images

MATCHUP Padres San Diego Mets New York
Team Records 82-69 78-73
Where Citi Field, Queens, New York
When Tuesday, September 16, 2025
Time 07:10 PM EDT
TV SNY

In this article, we will formulate a Padres vs Mets Prediction for this MLB game on Tuesday, September 16th at the Citi Field in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

New York Mets Preview

The New York Mets have a 77-73 record this season and are sitting on the second place of the NL East. The Mets have a 46-29 home record and are 70-72 in over/under. They are coming off a 5-2 home victory over the Rangers, that ended their 8-game losing streak. Over is 4-2 in their last 6 games and are playing the Cubs and the Nationals next.

The Mets have a .249 batting average this season, .327 OBP and .426 slugging percentage. New York’s pitching staff has a 4.01 ERA and 1.34 WHIP.  Francisco Lindor leads the Mets with 157 hits, while Pete Alonso leads the team in batting average with .266. He also adds a team-high 117 RBI, while Juan Soto adds team-high 40 home runs.

Clay Holmes (R) is the projected starting pitcher for the Mets, and he has a 11-8 record, 3.75 ERA and 1.35 WHIP.

San Diego Padres Preview

The San Diego Padres have an 82-68 record this season and are sitting on the second place of the NL West. They have a 35-40 road record, and are 63-81 in over/under. The Padres are coming off a 2-4 home defeat by the Reds, that ended their three-game winning streak. Under is 4-1 in their last 5 games and are playing the White Sox and the Brewers next. 

The Padres have a .252 batting average this season, .321 OBP and .388 Slugging percentage. San Diego’s pitching staff has a 3.64 ERA and 1.20 WHIP. Louis Arraez leads the Padres with 165 hits, and he is the team’s best hitter with a .286 batting average. Manny Machado leads the team both in RBI, with 88, and in home runs, with 25. 

Michael King (R) is the projected starting pitcher for the Padres, and he has a 4-2 record, 2.87 ERA and 1.07 WHIP.

San Diego Padres @ New York Mets Betting Trends: September 16, 2025

Why the New York Mets will win

Why the San Diego Padres will win

Total Runs Facts

New York Mets Player Prop Facts

San Diego Padres Player Prop Facts

Matchup/League Facts

Padres vs Mets Prediction

The Padres have won their last four meetings against the Mets, but the Mets have won their last three meetings in New York. Under is 3-1 in their last 4 meetings.

In this Padres vs Mets Prediction, the Mets are coming as -115 home favorites. The Mets have been playing pretty bad baseball lately, and now are facing a Padres team that fights with the Dodgers for the first place of the NL West, and are putting one of their best pitchers on the mound, in Michael King. San Diego has the second-best bullpen ERA in baseball, and are better against right-handed pitching, so I like them as small road dogs in this spot. Take the San Diego Padres on the moneyline on the road.

Nikos Lagouretos's Pick: San Diego Padres ML

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