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San Diego Padres vs New York Mets Prediction 9/18/2025 Today’s MLB Picks

Sep 17, 2025; New York City, New York, USA; New York Mets right fielder Juan Soto (22) hits a home run during the fifth inning against the San Diego Padres at Citi Field. Mandatory Credit: Vincent Carchietta-Imagn Images

Sep 17, 2025; New York City, New York, USA; New York Mets right fielder Juan Soto (22) hits a home run during the fifth inning against the San Diego Padres at Citi Field. Mandatory Credit: Vincent Carchietta-Imagn Images

MATCHUP Padres San Diego Mets New York
Team Records 83-70 79-74
Where Citi Field, Queens, New York
When Thursday, September 18, 2025
Time 01:10 PM EDT
TV MLBN

In this article, we will formulate a Padres vs Mets Prediction for this MLB game on Thursday, September 18th at the Citi Field in the third game of this series, with both teams being tied 1-1 wins. Let’s take a look at the prediction for this MLB matchup.

New York Mets Preview

The New York Mets have a 78-74 record this season and are sitting on the second place of the NL East. The Mets have a 47-30 home record and are 72-72 in over/under. They are coming off a 3-7 home defeat by the Padres, that ended their two-game winning streak. Over is 6-2 in their last 8 games and are playing the Cubs and the Nationals next.

The Mets have a .250 batting average this season, .327 OBP and .429 slugging percentage. New York’s pitching staff has a 4.03 ERA and 1.34 WHIP.  Francisco Lindor leads the Mets with 160 hits, while Pete Alonso leads the team in batting average with .270. He also adds a team-high 119 RBI, while Juan Soto adds team-high 41 home runs.

Jonah Tong (R) is the projected starting pitcher for the Mets, and he has a 1-2 record, 8.49 ERA and 1.71 WHIP.

San Diego Padres Preview

The San Diego Padres have an 83-69 record this season and are sitting on the second place of the NL West. They have a 36-41 road record, and are 65-81 in over/under. The Padres are coming off a 7-4 road victory over the Mets, that ended their two-game losing streak. Over is 4-0 in their last 4 games and are playing the White Sox and the Brewers next. 

The Padres have a .252 batting average this season, .322 OBP and .390 Slugging percentage. San Diego’s pitching staff has a 3.67 ERA and 1.20 WHIP. Louis Arraez leads the Padres with 168 hits, and he is the team’s best hitter with a .287 batting average. Manny Machado leads the team both in RBI, with 92, and in home runs, with 26. 

Randy Vasquez (R) is the projected starting pitcher for the Padres, and he has a 5-6 record, 3.72 ERA and 1.35 WHIP.

San Diego Padres @ New York Mets Betting Trends: September 18, 2025

Why the New York Mets will win

Why the San Diego Padres will win

Total Runs Facts

New York Mets Player Prop Facts

San Diego Padres Player Prop Facts

Matchup/League Facts

Padres vs Mets Prediction

The Padres are 5-1 in their last 6 meetings against the Mets, but the Mets are 4-1 in their last 5 meetings in New York. Over is 6-2 in their last 8 meetings.

In this Padres vs Mets Prediction, the Mets are coming as -135 home favorites. This like makes no sense, as the Mets are putting Jonah Tong on the mound, who has 14 earned runs in his three starts this season. On the flip side, Randy Vasquez has been solid this season and he has been in great form lately, with a 4-1 record and 3.24 ERA across his last 5 starts. San Diego has the best bullpen in baseball and are better against right-handed pitching, so I really like them in this spot as road dogs. Take the San Diego Padres and the plus money in this one.

Nikos Lagouretos's Pick: San Diego Padres ML

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