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San Francisco Giants vs Los Angeles Dodgers Prediction 9/18/2025 Today’s MLB Picks

Sep 17, 2025; Los Angeles, California, USA; Los Angeles Dodgers shortstop Mookie Betts (50) makes a throw to first base against the Philadelphia Phillies in the second inning at Dodger Stadium. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images

Sep 17, 2025; Los Angeles, California, USA; Los Angeles Dodgers shortstop Mookie Betts (50) makes a throw to first base against the Philadelphia Phillies in the second inning at Dodger Stadium. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images

MATCHUP Giants San Francisco Dodgers Los Angeles
Team Records 76-77 86-67
Where Dodger Stadium, Los Angeles, California
When Thursday, September 18, 2025
Time 10:10 PM EDT
TV MLBN

The San Francisco Giants and the Los Angeles Dodgers meet Thursday in MLB action from Dodger Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Francisco Giants vs. Los Angeles Dodgers prediction.

Starting Pitching Matchup

The San Francisco Giants will send out Logan Webb for the start here and Webb is 14-10 with a 3.34 ERA and 206 strikeouts his season. In his last five starts against the Dodgers, Webb is 2-1 with a 6.35 ERA and 25 strikeouts. Yoshinobu Yamamoto will start for the Dodgers here and is 11-8 with a 2.66 ERA and 187 strikeouts this season. In his career, Yamamoto is 0-1 with a 3.70 ERA and 27 strikeouts against the San Francisco Giants.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to add on to their 5-1 win over the Arizona Diamondbacks last time out to sit at 76-76 this season. After this series, the Giants will head home for a series against the St. Louis Cardinals.

Giants Looking To Keep Playoff Hopes Alive

Jung Hoo Lee has 139 hits including a team-high 30 doubles along with 11 triples, 8 home runs and 52 RBIs with 10 stolen bases while Heliot Ramos has 149 hits with 24 doubles, 17 home runs and 61 RBIs. Wilmer Flores also 16 home runs and 70 RBIs while Tyler Fitzgerald has 9 stolen bases as well on the year. Matt Chapman also has 99 hits with 21 home runs and 58 RBIs along with 20 doubles and Willy Adames has 126 hits with 20 doubles, 28 home runs and 82 RBIs of his own this season. 

Los Angeles Dodgers Recap

The Los Angeles Dodgers come into this game looking to build on a 5-0 win over the Philadelphia Phillies last time out to sit at 85-67 this season. After this series, the Dodgers will head on the road for a series against the Arizona Diamondbacks.

Dodgers Snap Losing Skid

Shohei Ohtani has 162 hits including 22 doubles, 51 home runs, 95 RBIs and 8 triples. Michael Conforto has 78 hits with 20 doubles while Teoscar Hernandez has 119 hits with 24 home runs, 28 doubles and 84 RBIs as well this season. Ohtani has a team-high 19 stolen bases while Max Muncy has 10 doubles but also has 73 strikeouts so far this season. Mookie Betts has also chipped in 19 home runs and 78 RBIs as well on the year. Freddie Freeman has also logged 155 hits with a team-high 39 doubles, 21 home runs and 83 RBIs. Andy Pages also has 151 hits with 25 doubles, 25 home runs and 81 RBIs as well this season.

San Francisco Giants @ Los Angeles Dodgers Betting Trends: September 18, 2025

Why the Los Angeles Dodgers will win

Why the San Francisco Giants will win

Total Runs Facts

Los Angeles Dodgers Player Prop Facts

San Francisco Giants Player Prop Facts

Matchup/League Facts

San Francisco Giants vs. Los Angeles Dodgers Prediction

I’m on the Dodgers here. Yamamoto has had some slight issues in his career against the Dodgers, but it’s nothing compared to the issues that Logan Webb has had opposite the Los Angeles Dodgers. The Dodgers are still a potent lineup and while the Giants have played well as of late and got themselves back in the wild card hunt, Logan Webb has just been struggling overall and against a Dodgers lineup that’s had his number, I don’t see it getting any better here. Give me the Dodgers.

Chris Ruffolo's Pick: Los Angeles Dodgers -165

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