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San Francisco Giants vs St. Louis Cardinals Prediction 9/7/2025 Today’s MLB Picks

Sep 5, 2025; St. Louis, Missouri, USA;  St. Louis Cardinals catcher Jimmy Crooks (8) catches a pop up hit by San Francisco Giants left fielder Heliot Ramos (not pictured) during the ninth inning at Busch Stadium. Mandatory Credit: Jeff Curry-Imagn Images

Sep 5, 2025; St. Louis, Missouri, USA; St. Louis Cardinals catcher Jimmy Crooks (8) catches a pop up hit by San Francisco Giants left fielder Heliot Ramos (not pictured) during the ninth inning at Busch Stadium. Mandatory Credit: Jeff Curry-Imagn Images

MATCHUP Giants San Francisco Cardinals St. Louis
Team Records 72-71 72-72
Where Busch Stadium, St. Louis, Missouri
When Sunday, September 7, 2025
Time 02:15 PM EDT
TV FanDuel SN MW

In this article, we will formulate a Giants vs Cardinals Prediction for this MLB game on Sunday, September 7th at the Busch Stadium in the third game of this series, with both teams being tied 1-1 wins. Let’s take a look at the prediction for this MLB matchup.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 71-72 record this season and are sitting on the 4th place of the NL Central. The Cardinals have a 40-34 home record and are 72-63 in over/under. They are coming off a 3-2 home victory over the Giants, and are 3-1 in their last 4 games. Under is 3-1 in their last 4 games and are playing the Brewers and the Mariners next.

The Cardinals have a .246 batting average this season, .314 OBP and .382 Slugging percentage. Saint Louis’ pitching staff has a 4.28 ERA and 1.32 WHIP. Alec Burleson leads the Cardinals with 123 hits, and he is the team’s best hitter with a .286 batting average. Wilson Contreras leads the team in RBI, with 78, adding a team-high 20 home runs.

Sonny Gray (R) is the projected starting pitcher for the Cardinals, and he has a 12-8 record, 4.43 ERA and 1.23 WHIP.

San Francisco Giants Preview

The San Francisco Giants have a 72-70 record this season and are sitting on the third place of the NL West. They have a 37-36 road record and are 67-69 in over/under. They are coming off a 2-3 road defeat by the Cardinals, that ended their five-game winning streak. Over is 6-2 in their last 8 games and are playing the Dodgers and the Diamondbacks next.

The Giants have a .239 batting average this season, .314 OBP and .391 Slugging percentage. San Francisco’s pitching staff has a 3.76 ERA and 1.28 WHIP.  Heliot Ramos leads the Giants with 145 hits and is the team’s best hitter, with a .269 batting average. Willy Adames leads the team in RBI with 78, adding a team-high 27 home runs. 

Kai-Wei Teng (R) is the projected starting pitcher for the Giants, and he has a 2-3 record, 7.23 ERA and 1.71 WHIP.

San Francisco Giants @ St. Louis Cardinals Betting Trends: September 7, 2025

Why the St. Louis Cardinals will win

Why the San Francisco Giants will win

Total Runs Facts

St. Louis Cardinals Player Prop Facts

San Francisco Giants Player Prop Facts

Matchup/League Facts

Giants vs Cardinals Prediction

The Cardinals are 6-2 in their last 8 head-to-head meetings against the Giants, and are 4-1 in their last 5 meetings in Saint Louis. Over is 8-2 in their last 10 meetings.

In this Giants vs Cardinals Prediction, the Cardinals are coming as -150 home favorites. I no way shape or form I am going to back Kai-Wei Teng to win on the road, even if the Giants are playing good baseball lately. Gray has been great at home for the Cardinals, with a 3.98 home ERA, and I expect the Cardinals to ride the momentum of yesterday’s win, and with a clear advantage on the mound, take care of business at home today.

Nikos Lagouretos's Pick: St. Louis Cardinals -150

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