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Seattle Mariners vs Houston Astros Prediction 9/19/2025 Today’s MLB Picks

Sep 17, 2025; Houston, Texas, USA; Houston Astros second baseman Jose Altuve (27) forces Texas Rangers shortstop Ezequiel Duran (20) out at second base and turns the double play in the eighth inning at Daikin Park. Mandatory Credit: Thomas Shea-Imagn Images

Sep 17, 2025; Houston, Texas, USA; Houston Astros second baseman Jose Altuve (27) forces Texas Rangers shortstop Ezequiel Duran (20) out at second base and turns the double play in the eighth inning at Daikin Park. Mandatory Credit: Thomas Shea-Imagn Images

MATCHUP Mariners Seattle Astros Houston
Team Records 85-69 84-70
Where Daikin Park, Houston, Texas
When Friday, September 19, 2025
Time 08:10 PM EDT
TV MLB.TV

The Seattle Mariners and Houston Astros meet Friday in MLB action at Daikin Park. Here’s a Seattle Mariners vs Houston Astros Prediction. This article will include a Seattle Mariners vs Houston Astros Pick.

Seattle Mariners Betting Preview

The Seattle Mariners are 84-69 on the year and play the Rockies and Dodgers next. The Seattle Mariners are batting .244 on the season, have a .320 OBP, and a .419 slugging percentage. The Seattle Mariners pitching staff has a 3.91 ERA and a 1.24 WHIP. Julio Rodriguez leads the Seattle Mariners with 168 hits and 93 RBI, while J.P. Crawford and Cal Raleigh have combined for 283 hits and 172 RBI.

Bryan Woo gets the ball for the Seattle Mariners, and he is 14-7 with a 3.02 ERA and 191 strikeouts this season. Woo is 1-2 with a 3.42 ERA and 20 strikeouts in his career against the Houston Astros.

Houston Astros Betting Preview

The Houston Astros are 84-69 on the year and play the Athletics and Angels next. The Houston Astros are batting .252 on the season, have a .318 OBP, and a .400 slugging percentage. The Houston Astros pitching staff has a 3.83 ERA and a 1.22 WHIP. Jose Altuve leads the Houston Astros with 148 hits and 74 RBI while Jeremy Pena and Yainer Diaz have combined for 279 hits and 126 RBI.

Hunter Brown gets the ball for the Houston Astros, and he is 12-7 with a 2.27 ERA and 192 strikeouts this season. Brown is 1-3 with a 4.26 ERA and 50 strikeouts in his career against the Seattle Mariners.

Seattle Mariners @ Houston Astros Betting Trends: September 19, 2025

Why the Houston Astros will win

Why the Seattle Mariners will win

Total Runs Facts

Houston Astros Player Prop Facts

Seattle Mariners Player Prop Facts

Matchup/League Facts

Seattle Mariners vs Houston Astros Prediction

You can make a case for the Mariners as they’ve caught fire over the last month, and Woo has been solid this season with a 3.02 ERA and 0.94 WHIP. However, the Astros are at home, and they’re a team that knows how to win down the stretch. Brown has also been a top-10 pitcher in baseball with a 2.27 ERA and 1.00 WHIP. In 80 home innings, Brown has a 2.25 ERA and .183 allowed batting average. Brown has allowed 3 runs in his last 18.2 innings. Great series and even better pitching matchup. Give me the Astros.

Randy Chambers's Pick: Houston Astros

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