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Seattle Mariners vs Houston Astros Prediction 9/20/2025 Today’s MLB Picks

Sep 19, 2025; Houston, Texas, USA; Houston Astros shortstop Jeremy Pena (3) throws a fielded ball to first base after tagging out Seattle Mariners first baseman Josh Naylor (12) during the sixth inning at Daikin Park. Mandatory Credit: Erik Williams-Imagn Images

Sep 19, 2025; Houston, Texas, USA; Houston Astros shortstop Jeremy Pena (3) throws a fielded ball to first base after tagging out Seattle Mariners first baseman Josh Naylor (12) during the sixth inning at Daikin Park. Mandatory Credit: Erik Williams-Imagn Images

MATCHUP Mariners Seattle Astros Houston
Team Records 86-69 84-71
Where Daikin Park, Houston, Texas
When Saturday, September 20, 2025
Time 07:10 PM EDT
TV MLB.TV

In this article, we will formulate a Mariners vs Astros Prediction for this MLB game on Saturday, September 20th at the Daikin Park in the second game of this series, with the Mariners having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Houston Astros Preview

The Houston Astros have an 84-70 record this season and are sitting on the second place of the AL West. The Astros have a 46-33 home record and 70-78 in over/under. They are coming off a 0-4 home defeat by the Mariners, that ended their three-game winning streak. They are playing the Athletics and the Angels next.

The Astros have a .251 batting average this season, .317 OBP and .398 slugging percentage. Houston’s pitching staff has a 3.83 ERA and 1.22 WHIP. Jose Altuve leads the Astros with 148 hits, adding a team-high 26 home runs. Jeremy Pena is the team’s best hitter with a .303 batting average, while Christian Walker leads the team in RBI with 82. 

Framber Valdez (L) is the projected starting pitcher for the Astros, and he has a 12-10 record, 3.59 ERA and 1.22 WHIP.

Seattle Mariners Preview

The Seattle Mariners have an 85-69 record this season and are sitting on the second place of the AL West. The Mariners have a 37-42 road record and are 84-64 in over/under. They are coming off a 4-0 road victory over the Astros, and have six consecutive wins. Over is 6-4 in their last 10 games and are playing the Rockies and the Dodgers next.

The Mariners have a .244 batting average this season, .320 OBP and .420 Slugging percentage. Seattle’s pitching staff has a 3.989 ERA and 1.23 WHIP. Julio Rodriguez leads the Mariners in hits with 169, and he is the team’s best hitter with a .269 batting average. Cal Raleigh leads the team both in RBI with 118, and in home runs with 56.

George Kirby (R) is the projected starting pitcher for the Mariners, and he has a 9-7 record, 4.46 ERA and 1.23 WHIP.

Seattle Mariners @ Houston Astros Betting Trends: September 20, 2025

Why the Houston Astros will win

Why the Seattle Mariners will win

Total Runs Facts

Houston Astros Player Prop Facts

Seattle Mariners Player Prop Facts

Matchup/League Facts

Mariners vs Astros Prediction

The Mariners are 3-1 in their last 4 head-to-head meetings against the Astros, but the Astros are 3-2 in their last 5 meetings in Houston. Under is 4-0 in their last 4 meetings in Houston.

In this Mariners vs Astros Prediction, both teams are coming at a pickem price. This is a huge matchup as both teams are fighting for the first place of the AL West, and I like the value with the home team in this one. Valdez has been elite at home for the Astros, with a 2.21 home ERA and has only one earned run in two starts against the Mariners this season. On the flip side, Kirby has been terrible on the road for the Mariners, with a 5.74 ERA, and was torched in his only start against the Astros this season, for 5 earned runs. Take the Houston Astros for a bounce-back win at home in this one.

Nikos Lagouretos's Pick: Houston Astros ML

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