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Seattle Mariners vs Houston Astros Prediction 9/21/2025 Today’s MLB Picks

Sep 20, 2025; Houston, Texas, USA; Seattle Mariners right fielder Victor Robles (10) makes a diving catch during the ninth inning against the Houston Astros at Daikin Park. Mandatory Credit: Troy Taormina-Imagn Images

Sep 20, 2025; Houston, Texas, USA; Seattle Mariners right fielder Victor Robles (10) makes a diving catch during the ninth inning against the Houston Astros at Daikin Park. Mandatory Credit: Troy Taormina-Imagn Images

MATCHUP Mariners Seattle Astros Houston
Team Records 87-69 84-72
Where Daikin Park, Houston, Texas
When Sunday, September 21, 2025
Time 07:00 PM EDT
TV ESPN
The Seattle Mariners and Houston Astros meet Sunday in MLB action at Daikin Park. Here’s a Seattle Mariners vs Houston Astros Prediction. This article will include a Seattle Mariners vs Houston Astros Pick.

Seattle Mariners Betting Preview


The Seattle Mariners are 86-69 on the year and play the Rockies and Dodgers next. The Seattle Mariners are batting .245 on the season, have a .320 OBP, and a .420 slugging percentage. The Seattle Mariners pitching staff has a 3.89 ERA and a 1.23 WHIP. Julio Rodriguez leads the Seattle Mariners with 170 hits and 94 RBI, while J.P. Crawford and Cal Raleigh have combined for 287 hits and 173 RBI.

Logan Gilbert gets the ball for the Seattle Mariners, and he is 5-6 with a 3.53 ERA and 164 strikeouts this season. Gilbert is 5-4 with a 3.48 ERA and 69 strikeouts in his career against the Houston Astros.

Houston Astros Betting Preview


The Houston Astros are 84-71 on the year and play the Athletics and Angels next. The Houston Astros are batting .252 on the season, have a .317 OBP, and a .398 slugging percentage. The Houston Astros pitching staff has a 3.85 ERA and a 1.22 WHIP. Jose Altuve leads the Houston Astros with 150 hits and 74 RBI while Jeremy Pena and Yainer Diaz have combined for 283 hits and 130 RBI.

Jason Alexander gets the ball for the Houston Astros, and he is 4-1 with a 4.04 ERA and 60 strikeouts this season. This will be Alexander’s first career game against the Seattle Mariners.

Seattle Mariners @ Houston Astros Betting Trends: September 21, 2025


Why the Houston Astros will win

Why the Seattle Mariners will win

Total Runs Facts

Houston Astros Player Prop Facts

Seattle Mariners Player Prop Facts

Matchup/League Facts

Seattle Mariners vs Houston Astros Prediction


The Astros are 11-1 with Alexander since getting him from the Athletics, and he’s allowed just 14 hits and 4 earned runs in his last 16.2 innings. It’s hard to argue with that sort of success. However, the Mariners have lost one game since September 6, and they’re in the driver’s seat in the AL West. Sometimes a team just catches a hot streak and there’s nothing you can do about it. The M’s have caught fire at the right time, and I’m not excited to step in front of it. Give me the Mariners.

Randy Chambers's Pick: Seattle Mariners

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