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St. Louis Cardinals vs Milwaukee Brewers Prediction 9/12/2025 Today’s MLB Picks

Jun 15, 2025; Milwaukee, Wisconsin, USA;  Milwaukee Brewers center fielder Jackson Chourio (11) bats during the game against the St. Louis Cardinals at American Family Field. Mandatory Credit: Jeff Hanisch-Imagn Images

Jun 15, 2025; Milwaukee, Wisconsin, USA; Milwaukee Brewers center fielder Jackson Chourio (11) bats during the game against the St. Louis Cardinals at American Family Field. Mandatory Credit: Jeff Hanisch-Imagn Images

MATCHUP Cardinals St. Louis Brewers Milwaukee
Team Records 72-76 90-58
Where American Family Field, Milwaukee, Wisconsin
When Friday, September 12, 2025
Time 08:10 PM EDT
TV FanDuel SN WI
In this article, we will formulate a Cardinals vs Brewers Prediction for this MLB game on Friday, September 12th at the American Family Field the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Milwaukee Brewers Preview

The Milwaukee Brewers have an 89-58 record this season and are sitting on the first place of the NL Central. They have a 46-26 home record and are 70-72 in over/under. They are coming off a 3-6 road defeat by the Rangers, and have three straight losses, having being swept in that series. Over is 3-1 in their last 4 games and are playing the Cardinals and the Angels next.

The Brewers have a .260 batting average this season, .333 OBP and .408 Slugging percentage. Milwaukee’s pitching staff has a 3.63 ERA and 1.23 WHIP. Brice Turang leads the Brewers with 154 hits, while Christian Yelich leads the team in RBI, with 93, adding a team-high 27 home runs. Sal Frelick is the team’s best hitter with a .294 batting average.

Quinn Priester (R) is the projected starting pitcher for the Brewers, and he has a 12-2 record, 3.25 ERA and 1.23 WHIP.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 72-75 record this season and are sitting on the 4th place of the NL Central. The Cardinals have a 31-41 road record and are 73-66 in over/under. They are coming off a 3-5 road defeat by the Mariners, and have back-to-back losses. Under is 5-2 in their last 7 games and are playing the Brewers and the Reds next.

The Cardinals have a .244 batting average this season, .313 OBP and .379 Slugging percentage. Saint Louis’ pitching staff has a 4.26 ERA and 1.31 WHIP. Alec Burleson leads the Cardinals with 125 hits, and he is the team’s best hitter with a .282 batting average. Wilson Contreras leads the team in RBI, with 78, adding a team-high 20 home runs.

Andre Pallante (R) is the projected starting pitcher for the Cardinals, and he has a 6-13 record, 5.28 ERA and 1.43 WHIP.

St. Louis Cardinals @ Milwaukee Brewers Betting Trends: September 12, 2025


Why the Milwaukee Brewers will win


Why the St. Louis Cardinals will win

Total Runs Facts

Milwaukee Brewers Player Prop Facts

St. Louis Cardinals Player Prop Facts

Matchup/League Facts

Cardinals vs Brewers Prediction

The Brewers are 4-1 in their last 5 meetings against the Cardinals, but both teams are tied 3-3 wins in their last 6 meetings in Milwaukee. Under is 6-2 in their last 8 meetings.

In this Cardinals vs Brewers Prediction, the Brewers are coming as -185 home favorites. Milwaukee has a huge pitching advantage, as Priester has been a winning machine this season, with a 12-2 record, with the Brewers having won the last 14 games he has started. On the flip side, Pallante has been mediocre this season and in poor form lately, with a 1-4 record and 6.84 ERA in his last 5 starts. Milwaukee has both a better bullpen and a better offense and I expect to dominate this game for a bounce-back win.

Nikos Lagouretos's Pick: Milwaukee Brewers -180

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