St. Louis Cardinals vs Milwaukee Brewers Prediction 9/14/2025 Today’s MLB Picks

Nikos Lagouretos

2 months ago

Sep 13, 2025; Milwaukee, Wisconsin, USA; Milwaukee Brewers shortstop Joey Ortiz (3) throws out St. Louis Cardinals left fielder Alec Burleson (not pictured) in the sixth inning at American Family Field. Mandatory Credit: Benny Sieu-Imagn Images

MATCHUP	Cardinals St. Louis	Brewers Milwaukee
Team Records	73-77	91-59
Where	American Family Field, Milwaukee, Wisconsin
When	Sunday, September 14, 2025
Time	02:10 PM EDT
TV	FanDuel SN WI

In this article, we will formulate a Cardinals vs Brewers Prediction for this MLB game on Sunday, September 14th at the American Family Field the third game of this series, with the Brewers having the 2-0 lead. Let’s take a look at the prediction for this MLB matchup.

Milwaukee Brewers Preview

The Milwaukee Brewers have a 91-58 record this season and are sitting on the first place of the NL Central. They have a 48-26 home record and are 72-72 in over/under. They are coming off a 9-8 home victory over the Cardinals, and have back-to-back wins. Over is 5-1 in their last 6 games and are playing the Cardinals and the Angels next.

The Brewers have a .261 batting average this season, .333 OBP and .408 Slugging percentage. Milwaukee’s pitching staff has a 3.63 ERA and 1.24 WHIP. Brice Turang leads the Brewers with 155 hits, while Christian Yelich leads the team in RBI, with 96, adding a team-high 28 home runs. Sal Frelick is the team’s best hitter with a .296 batting average.

Jose Quintana (L) is the projected starting pitcher for the Brewers, and he has a 11-6 record, 3.88 ERA and 1.28 WHIP.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 72-77 record this season and are sitting on the 4th place of the NL Central. The Cardinals have a 31-43 road record and are 75-66 in over/under. They are coming off an 8-9 road defeat by the Brewers, and have five straight losses. Over is 3-1 in their last 4 games and are playing the Brewers and the Reds next.

The Cardinals have a .245 batting average this season, .314 OBP and .380 Slugging percentage. Saint Louis’ pitching staff has a 4.30 ERA and 1.32 WHIP. Alec Burleson leads the Cardinals with 128 hits, and he is the team’s best hitter with a .283 batting average. Wilson Contreras leads the team in RBI, with 79, adding a team-high 20 home runs.

Miles Mikolas (R) is the projected starting pitcher for the Cardinals, and he has a 7-10 record, 4.84 ERA and 1.32 WHIP.

St. Louis Cardinals @ Milwaukee Brewers Betting Trends: September 14, 2025

Probable Starting Pitcher: Jose Quintana Record this season: 11-6 ERA: 3.88
Home Record: 4-4
Last 5 against Cardinals: 2-2

Why the Milwaukee Brewers will win

The Brewers have won each of their last 10 games against NL Central opponents that held a losing record.
The Cardinals have lost each of their last six road games.
The Cardinals have failed to cover the run line in each of their last eight Sunday day games.
The Brewers have covered the run line in nine of their last 10 games against NL Central opponents that held a losing record.
The Brewers have won the first inning in three of their last four day games.
The Brewers have led after 3 innings in each of their last five day games against NL Central opponents that held a losing record.
The Cardinals have trailed after 5 innings in each of their last seven road day games.

Probable Starting Pitcher: Miles Mikolas Record this season: 7-10 ERA: 4.84
Road Record: 3-6
Last 5 against Brewers: 2-2

Why the St. Louis Cardinals will win

The Brewers have lost four of their last five games as home favorites after playing the previous day.
The Cardinals have won six of their last eight games as underdogs against National League opponents following a loss.
The Brewers have failed to cover the run line in each of their last six home games following a win.
The Cardinals have covered the run line in nine of their last 10 day games at American Family Field following a loss.
The Brewers have trailed after 5 innings in four of their last five games.
The Brewers have trailed after 3 innings in three of their last four games.

Total Runs Facts

Eight of the Cardinals’ last nine games following an extra innings loss have gone OVER the total runs line.
Seven of the Brewers’ last eight home games against NL Central opponents have gone OVER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Cardinals’ last eight road games against NL Central opponents.
The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the last 10 day games between the Cardinals and Brewers at American Family Field.

Milwaukee Brewers Player Prop Facts

Christian Yelich has hit a home run in three of the Brewers’ last five home games against NL Central opponents.
Jackson Chourio has recorded two hits in each of his last four home appearances against opponents that held a losing record.
Jose Quintana has recorded a win in each of his last four appearances against NL Central opponents that held a losing record.
Jose Quintana has recorded six or more strikeouts in three of his last four appearances against NL Central opponents that held a losing record.
Sal Frelick ranks 9th amongst qualified players for Batting Average (.296) this season.

St. Louis Cardinals Player Prop Facts

Willson Contreras has hit a home run in five of his last 10 road appearances after playing the previous day.
Miles Mikolas has recorded a win in eight of his last 10 appearances at American Family Field against opponents that held a winning record.
Miles Mikolas has recorded three or more strikeouts in each of his last 19 appearances against the Brewers.
Brendan Donovan has recorded at least one hit in each of his last nine appearances against the Brewers.
Victor Scott II ranks T10th in the league in Steals (32) this season.

Matchup/League Facts

The Brewers rank 2nd in the league for runs scored this season (760).
The Brewers rank 2nd in the league for on-base percentage this season (.334).
The Cardinals rank T29th in the league for triples this season (8).
The Cardinals rank 29th in the league for strikeouts this season (1100).

Cardinals vs Brewers Prediction

The Brewers are 6-1 in their last 7 meetings against the Cardinals, and are 5-1 in their last 6 meetings in Milwaukee. Over is 3-1 in their last 4 meetings.

In this Cardinals vs Brewers Prediction, the Brewers are coming as -185 home favorites. Quintana has been a better option than Mikolas this season, but he has been far weaker at home, with a 4.97 home ERA, and he has been in poor form lately, with 14 earned runs in his last three starts. Mikolas has also been terrible on the road, with a 6.54 road ERA, and both teams average 9.6 runs per game combined this season. Both games of this series have been high-scoring ones, with 10 and 17 total runs, so take the over 8.5 runs in this one.