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Tampa Bay Rays vs Chicago Cubs Prediction 9/13/2025 Today’s MLB Picks

Sep 12, 2025; Chicago, Illinois, USA;  Chicago Cubs first baseman Michael Busch (29) hits an RBI single against the Tampa Bay Rays during the second inning at Wrigley Field. Mandatory Credit: Matt Marton-Imagn Images

Sep 12, 2025; Chicago, Illinois, USA; Chicago Cubs first baseman Michael Busch (29) hits an RBI single against the Tampa Bay Rays during the second inning at Wrigley Field. Mandatory Credit: Matt Marton-Imagn Images

MATCHUP Rays Tampa Bay Cubs Chicago
Team Records 73-75 84-64
Where Wrigley Field, Chicago, Illinois
When Saturday, September 13, 2025
Time 02:20 PM EDT
TV Marquee Sports Net

In this article, we will formulate a Rays vs Cubs Prediction for this MLB game on Saturday, September 13th at the Wrigley Field the second game of this series, with the Cubs having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Chicago Cubs Preview

The Chicago Cubs have an 84-63 record this season and are sitting on the second place of the NL Central. The Cubs have a 45-28 home record and are 66-70 in over/under. They are coming off a 6-4 home victory over the Rays, and have three straight wins. Under is 6-3 in their last 9 games and are playing the Pirates and the Reds next.

The Cubs have a .249 batting average this season, .320 OBP and .426 Slugging percentage. Chicago’s pitching staff has a 3.86 ERA and 1.19 WHIP. Nico Hoerner leads the Cubs with 158 hits, and he is the team’s best hitter with a .296 batting average. Seiya Suzuki leads the team in RBI, with 91, adding a team-high 28 home runs.

Colin Rea (R) is the projected starting pitcher for the Cubs, and he has a 10-6 record, 4.20 ERA and 1.31 WHIP.

Tampa Bay Rays Preview

The Tampa Bay Rays have a 72-75 record this season and are sitting on the 4th place of the AL East. The Rays have a 34-39 road record and are 64-74 in over/under. They are coming off a 4-6 road defeat by the Cubs, and are 1-6 in their last 7 games. Over is 8-4 in their last 12 games and are playing the Red Sox and the Blue Jays next.

The Rays have a .251 batting average this season, .313 OBP and .402 slugging percentage. Tampa’s pitching staff has a 3.90 ERA and 1.21 WHIP.  Yandy Diaz leads the Rays with 157 hits, and he is the team’s best hitter with .290 batting average. Junior Caminero leads the team in RBI, with 106 and in home runs, with 42.

Drew Rasmussen (R) is the projected starting pitcher for the Rays, and he has a 10-5 record, 2.64 ERA and 0.98 WHIP.

Tampa Bay Rays @ the Chicago Cubs Betting Trends: September 13, 2025

Why the Chicago Cubs will win

Why the Tampa Bay Rays will win

Total Runs Facts

Chicago Cubs Player Prop Facts

Tampa Bay Rays Player Prop Facts

Matchup/League Facts

Rays vs Cubs Prediction

The Rays are 3-2 in their last 5 meetings against the Cubs, but the Cubs are 3-1 in their last 4 meetings in Chicago. Under is 6-1 in their last 7 meetings.

In this Rays vs Cubs Prediction, the Cubs are coming as -120 home favorites. The Rays are putting their ace on the mound in Drew Rasmussen, who has been elite this season, and he is coming off a shutout start against the Guardians. On the flip side, Rea has 9 earned runs in his last two starts, and he is far the weakest option between the two starting pitchers. The Rays have a better bullpen, and are far better against right-handed pitching, so I like them in a bounce back spot today. Take the Tampa Bay Rays and the plus money on the road in this one.

Nikos Lagouretos's Pick: Tampa Bay Rays ML

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